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Cyrus N, Blechman AB, Leboeuf M, et al. Effect of Quadrivalent Human Papillomavirus Vaccination on Oral Squamous Cell Papillomas. JAMA Dermatol. 2015;151(12):1359-1363doi: 10.1001/jamadermatol.2015.2805.
Cyrus, N., Blechman, A. B., Leboeuf, M., Belyaeva, E. A., de Koning, M. N., Quint, K. D., & Stern, J. J. (2015). Effect of Quadrivalent Human Papillomavirus Vaccination on Oral Squamous Cell Papillomas. JAMA dermatology, 151(12), 1359-1363. https://doi.org/10.1001/jamadermatol.2015.2805
Cyrus, Nika, et al. "Effect of Quadrivalent Human Papillomavirus Vaccination on Oral Squamous Cell Papillomas." JAMA dermatology vol. 151,12 (2015): 1359-1363. doi: https://doi.org/10.1001/jamadermatol.2015.2805
Cyrus N, Blechman AB, Leboeuf M, Belyaeva EA, de Koning MN, Quint KD, Stern JJ. Effect of Quadrivalent Human Papillomavirus Vaccination on Oral Squamous Cell Papillomas. JAMA Dermatol. 2015 Dec 01;151(12):1359-1363. doi: 10.1001/jamadermatol.2015.2805. PMID: 26332141.
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JAMA Dermatol. 2015 Dec 01;151(12):1359-1363. doi: 10.1001/jamadermatol.2015.2805.

Effect of Quadrivalent Human Papillomavirus Vaccination on Oral Squamous Cell Papillomas.

JAMA dermatology

Nika Cyrus, Adam B Blechman, Matthew Leboeuf, Elizaveta A Belyaeva, Maurits N C de Koning, Koen D Quint, John J Stern

Affiliations

  1. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas.
  2. Department of Dermatology, University of Virginia Health System, Charlottesville.
  3. Department of Dermatology, University of Pennsylvania Health System, Philadelphia.
  4. Department of Pathology, Pennsylvania Hospital, Philadelphia.
  5. DDL Diagnostic Laboratory BV, Rijswijk, the Netherlands.
  6. DDL Diagnostic Laboratory BV, Rijswijk, the Netherlands6Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
  7. Division of Infectious Diseases, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia.

PMID: 26332141 DOI: 10.1001/jamadermatol.2015.2805

Abstract

IMPORTANCE: Cutaneous verruca vulgaris lesions (warts) and oral squamous cell papillomas are common lesions caused by human papillomavirus (HPV). Multiple reports have described cases of wart resolution following quadrivalent HPV vaccination. We report the case of a patient with chronic oral papillomas with resolution after quadrivalent HPV vaccination and perform a review of the literature.

OBSERVATIONS: An immunocompetent man in his 60s presented with chronic verrucous papules on the lips, tongue, and buccal mucosa refractory to multiple excisions. Biopsy showed squamous cell papilloma, and DNA sequencing revealed HPV-32. He received the quadrivalent HPV vaccine resulting in clearance of all lesions after 3 months. We found 8 reported cases of disseminated, recurrent warts with resolution after quadrivalent HPV vaccination. Improvement was seen within 4 weeks of vaccination, and resolution after 3 to 8 months.

CONCLUSIONS AND RELEVANCE: We report the case of recurrent oral papillomas caused by HPV-32 with complete resolution after quadrivalent HPV vaccination and reviewed reports of resolution of recalcitrant and disseminated warts after vaccination. Production of cross-protective immunoglobulins and cytotoxic T cells is a possible mechanism. There remains a critical need for randomized clinical trials to assess efficacy of quadrivalent HPV vaccination for treatment of oral squamous papillomas and cutaneous verruca vulgaris.

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