Display options
Cite
Dieter BP, Alicic RZ, Meek RL, et al. Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths. Diabetes Spectr. 2015;28(3):167-74doi: 10.2337/diaspect.28.3.167.
Dieter, B. P., Alicic, R. Z., Meek, R. L., Anderberg, R. J., Cooney, S. K., & Tuttle, K. R. (2015). Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths. Diabetes spectrum : a publication of the American Diabetes Association, 28(3), 167-74. https://doi.org/10.2337/diaspect.28.3.167
Dieter, Brad P, et al. "Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths." Diabetes spectrum : a publication of the American Diabetes Association vol. 28,3 (2015): 167-74. doi: https://doi.org/10.2337/diaspect.28.3.167
Dieter BP, Alicic RZ, Meek RL, Anderberg RJ, Cooney SK, Tuttle KR. Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths. Diabetes Spectr. 2015 Aug;28(3):167-74. doi: 10.2337/diaspect.28.3.167. PMID: 26300609; PMCID: PMC4536640.
Copy Download .nbib Format: NLM
Share it on

Diabetes Spectr. 2015 Aug;28(3):167-74. doi: 10.2337/diaspect.28.3.167.

Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths.

Diabetes spectrum : a publication of the American Diabetes Association

Brad P Dieter, Radica Z Alicic, Rick L Meek, Robert J Anderberg, Sheryl K Cooney, Katherine R Tuttle

Affiliations

  1. Providence Medical Research Center, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA.
  2. Providence Medical Research Center, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA ; Department of Medicine, University of Washington School of Medicine, Seattle, WA.
  3. Providence Medical Research Center, Providence Sacred Heart Medical Center and Children's Hospital, Spokane, WA ; Department of Medicine, University of Washington School of Medicine, Seattle, WA ; Division of Nephrology, University of Washington School of Medicine, Seattle, WA.

PMID: 26300609 PMCID: PMC4536640 DOI: 10.2337/diaspect.28.3.167

Abstract

IN BRIEF Current therapeutic approaches are only moderately efficacious at preventing the progression of diabetic kidney disease (DKD). As the number of people with DKD continues to rise worldwide, there is an urgent need for novel therapies. A better understanding of the root causes and molecular mechanisms of DKD pathogenesis has enabled the identification of numerous new therapeutic targets, including advanced glycation end products, reactive oxygen species, protein kinase C, and serum amyloid A. Although experimental studies have illustrated the potential of such approaches, challenges in clinical translation remain a barrier in therapeutic development. Advances in preclinical safety and efficacy evaluations and improved delivery systems may aid in clinical translation of novel DKD therapies.

References

  1. J Am Soc Nephrol. 2000 Sep;11(9):1656-66 - PubMed
  2. Oxid Med Cell Longev. 2012;2012:821936 - PubMed
  3. Am J Nephrol. 2011;33(4):289-97 - PubMed
  4. Int J Nanomedicine. 2012;7:417-33 - PubMed
  5. Diabetes Res Clin Pract. 1995 May;28(2):103-17 - PubMed
  6. Diabetes. 2011 Nov;60(11):3055-66 - PubMed
  7. Diabetologia. 2002 Jun;45(6):805-12 - PubMed
  8. Am J Pathol. 2004 Apr;164(4):1389-97 - PubMed
  9. Diabetes Care. 2000 Apr;23 Suppl 2:B21-9 - PubMed
  10. Am J Kidney Dis. 2012 Nov;60(5):850-86 - PubMed
  11. Am J Kidney Dis. 2015 Apr;65(4):634-6 - PubMed
  12. Diabetes. 2014 Sep;63(9):3091-103 - PubMed
  13. N Engl J Med. 2014 May 1;370(18):1768-9 - PubMed
  14. Am J Kidney Dis. 1998 Nov;32(5 Suppl 3):S112-9 - PubMed
  15. JAMA. 2003 Oct 22;290(16):2159-67 - PubMed
  16. Lancet. 1998 Sep 12;352(9131):854-65 - PubMed
  17. Kidney Int Suppl. 2003 Oct;(86):S64-70 - PubMed
  18. Lancet. 1998 Sep 12;352(9131):837-53 - PubMed
  19. N Engl J Med. 2011 Jul 28;365(4):327-36 - PubMed
  20. Nephrol Dial Transplant. 2004 Oct;19(10):2505-12 - PubMed
  21. N Engl J Med. 2009 Jan 8;360(2):129-39 - PubMed
  22. Science. 1996 May 3;272(5262):728-31 - PubMed
  23. Diabetes Care. 2003 Aug;26(8):2421-5 - PubMed
  24. Nephrol Dial Transplant. 2011 Nov;26(11):3474-84 - PubMed
  25. J Am Soc Nephrol. 2009 Mar;20(3):554-66 - PubMed
  26. Diabetes Care. 2005 Nov;28(11):2686-90 - PubMed
  27. N Engl J Med. 2013 Dec 26;369(26):2492-503 - PubMed
  28. Clin J Am Soc Nephrol. 2007 Jul;2(4):631-6 - PubMed
  29. J Exp Med. 1986 Dec 1;164(6):2006-17 - PubMed
  30. Lancet. 2007 Sep 8;370(9590):829-40 - PubMed
  31. Diabetes. 2012 Aug;61(8):2105-13 - PubMed
  32. Cell Physiol Biochem. 2009;24(5-6):627-34 - PubMed
  33. Nephrol Dial Transplant. 2013 Jul;28(7):1711-20 - PubMed
  34. Mol Cell Biol. 2003 Oct;23 (19):7068-81 - PubMed
  35. Diabetes. 2013 Apr;62(4):1167-74 - PubMed
  36. Ugeskr Laeger. 1999 Feb 15;161(7):949-52 - PubMed
  37. N Engl J Med. 2012 Dec 6;367(23):2204-13 - PubMed
  38. Lancet. 2008 Aug 16;372(9638):547-53 - PubMed
  39. Diabetologia. 2005 Mar;48(3):519-28 - PubMed
  40. Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E87-99 - PubMed
  41. J Am Soc Nephrol. 2012 Jan;23(1):131-6 - PubMed
  42. Diabetes. 2004 Aug;53(8):2101-9 - PubMed
  43. Diabetes Res Clin Pract. 1998 Aug;41(2):131-7 - PubMed
  44. Am J Nephrol. 2014;39(6):499-508 - PubMed
  45. Kidney Int. 2002 Mar;61(3):939-50 - PubMed
  46. Diabetes. 2006 Jan;55(1):225-33 - PubMed
  47. J Clin Invest. 1997 Jul 1;100(1):115-26 - PubMed
  48. Arch Intern Med. 2008 Dec 8;168(22):2440-7 - PubMed
  49. Diabetes Care. 2007 Apr;30(4):995-6 - PubMed
  50. Circulation. 2002 Oct 15;106(16):2067-72 - PubMed
  51. Metabolism. 2007 Feb;56(2):160-7 - PubMed
  52. N Engl J Med. 2001 Sep 20;345(12):861-9 - PubMed
  53. Exp Diabetes Res. 2008;2008:230837 - PubMed
  54. PLoS One. 2010 Mar 01;5(3):e9463 - PubMed
  55. Lab Invest. 2015 Mar;95(3):250-62 - PubMed
  56. Diabetes Care. 2000 Oct;23(10):1478-85 - PubMed
  57. Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1438-46 - PubMed
  58. Adv Chronic Kidney Dis. 2014 Mar;21(2):121-33 - PubMed
  59. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F808-19 - PubMed
  60. Expert Opin Drug Saf. 2006 Nov;5(6):835-45 - PubMed
  61. N Engl J Med. 2013 Nov 14;369(20):1892-903 - PubMed
  62. JAMA. 2011 Jun 22;305(24):2532-9 - PubMed
  63. Am J Nephrol. 2007;27(6):605-14 - PubMed
  64. Curr Opin Nephrol Hypertens. 2011 May;20(3):278-84 - PubMed
  65. Diabetes. 2003 Feb;52(2):512-8 - PubMed
  66. J Diabetes Complications. 2013 Jan-Feb;27(1):59-63 - PubMed

Publication Types