Display options
Cite
Malaguarnera G, Gagliano C, Salomone S, et al. Folate status in type 2 diabetic patients with and without retinopathy. Clin Ophthalmol. 2015;9:1437-42doi: 10.2147/OPTH.S77538.
Malaguarnera, G., Gagliano, C., Salomone, S., Giordano, M., Bucolo, C., Pappalardo, A., Drago, F., Caraci, F., Avitabile, T., & Motta, M. (2015). Folate status in type 2 diabetic patients with and without retinopathy. Clinical ophthalmology (Auckland, N.Z.), 91437-42. https://doi.org/10.2147/OPTH.S77538
Malaguarnera, Giulia, et al. "Folate status in type 2 diabetic patients with and without retinopathy." Clinical ophthalmology (Auckland, N.Z.) vol. 9 (2015): 1437-42. doi: https://doi.org/10.2147/OPTH.S77538
Malaguarnera G, Gagliano C, Salomone S, Giordano M, Bucolo C, Pappalardo A, Drago F, Caraci F, Avitabile T, Motta M. Folate status in type 2 diabetic patients with and without retinopathy. Clin Ophthalmol. 2015 Aug 07;9:1437-42. doi: 10.2147/OPTH.S77538. eCollection 2015. PMID: 26300625; PMCID: PMC4536839.
Copy Download .nbib Format: NLM
Share it on

Clin Ophthalmol. 2015 Aug 07;9:1437-42. doi: 10.2147/OPTH.S77538. eCollection 2015.

Folate status in type 2 diabetic patients with and without retinopathy.

Clinical ophthalmology (Auckland, N.Z.)

Giulia Malaguarnera, Caterina Gagliano, Salvatore Salomone, Maria Giordano, Claudio Bucolo, Antonino Pappalardo, Filippo Drago, Filippo Caraci, Teresio Avitabile, Massimo Motta

Affiliations

  1. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
  2. Department of Ophthalmology, University of Catania, Catania, Italy ; Neurovisual Science Technology (NEST), Catania, Catania, Italy.
  3. Gerontology and Bone Metabolic Disease Section, Department of Medical Sciences, University of Turin, Turin, Italy.
  4. Department of Medical and Paediatric Sciences, University of Catania, Italy.
  5. Department of Drug Sciences, University of Catania, Catania, Italy ; IRCCS Association Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy.
  6. Department of Ophthalmology, University of Catania, Catania, Italy.

PMID: 26300625 PMCID: PMC4536839 DOI: 10.2147/OPTH.S77538

Abstract

BACKGROUND: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy.

METHODS: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group.

RESULTS: We found higher plasma levels of homocysteine in the NPDR group compared to the control group (P<0.001) and in the PDR group compared to control group (P<0.001) and NPDR group (P<0.01). The severity of diabetic retinopathy was associated with lower folic acid and red cell folate levels, and a significant difference was observed between PDR and NPDR groups (P<0.05).

CONCLUSION: The folate status could play a role in the development and progression of diabetic retinopathy.

Keywords: diabetes mellitus; homocysteine; nonproliferative diabetic retinopathy; proliferative diabetic retinopathy

References

  1. BMJ. 2010 May 20;340:c2181 - PubMed
  2. Biomed Res Int. 2013;2013:943505 - PubMed
  3. J Am Coll Cardiol. 2011 Aug 30;58(10):1025-33 - PubMed
  4. J Nutr. 1999 Apr;129(4):913-6 - PubMed
  5. Am J Hypertens. 2002 Feb;15(2 Pt 1):157-63 - PubMed
  6. Acta Ophthalmol. 2011 Sep;89(6):515-21 - PubMed
  7. J Korean Med Sci. 2014 Jul;29(7):965-72 - PubMed
  8. J Nutr. 2002 Mar;132(3):439-42 - PubMed
  9. Br Med J. 1971 Jul 24;3(5768):246-7 - PubMed
  10. J Med Assoc Thai. 2004 Jul;87(7):780-7 - PubMed
  11. J Intern Med. 1998 Aug;244(2):169-74 - PubMed
  12. Med Clin (Barc). 2010 Jul 17;135(6):287-8 - PubMed
  13. J Intern Med. 2003 Nov;254(5):455-63 - PubMed
  14. Biomed Res Int. 2013;2013:650989 - PubMed
  15. Rev Endocr Metab Disord. 2008 Dec;9(4):315-27 - PubMed
  16. Biomed Res Int. 2014;2014:191497 - PubMed
  17. Int J Cardiol. 2002 Mar;82(3):269-77 - PubMed
  18. Tunis Med. 2006 May;84(5):279-81 - PubMed
  19. Med Clin (Barc). 2010 Jul 17;135(6):286-7 - PubMed
  20. Am J Clin Nutr. 2007 Nov;86(5):1414-9 - PubMed
  21. Front Biosci (Schol Ed). 2010 Jun 01;2:866-75 - PubMed
  22. Heart Vessels. 2000;15(3):135-43 - PubMed
  23. Nutr Rev. 2004 Jun;62(6 Pt 2):S3-12; discussion S13 - PubMed
  24. Crit Rev Food Sci Nutr. 2014;54(12):1599-616 - PubMed
  25. J Cell Biochem. 2001;82(3):491-500 - PubMed
  26. J Cardiovasc Dis Res. 2011 Apr;2(2):96-103 - PubMed
  27. PLoS One. 2014 Oct 09;9(10):e109878 - PubMed
  28. Scand J Clin Lab Invest. 1997 Oct;57(6):521-7 - PubMed
  29. Yao Xue Xue Bao. 2009 Feb;44(2):109-14 - PubMed

Publication Types