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Deb D, Bairy KL, Nayak V, et al. Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Adv Pharmacol Sci. 2015;2015:521718doi: 10.1155/2015/521718.
Deb, D., Bairy, K. L., Nayak, V., & Rao, M. (2015). Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Advances in pharmacological sciences, 2015521718. https://doi.org/10.1155/2015/521718
Deb, Debasree, et al. "Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats." Advances in pharmacological sciences vol. 2015 (2015): 521718. doi: https://doi.org/10.1155/2015/521718
Deb D, Bairy KL, Nayak V, Rao M. Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats. Adv Pharmacol Sci. 2015;2015:521718. doi: 10.1155/2015/521718. Epub 2015 Aug 02. PMID: 26300914; PMCID: PMC4537708.
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Adv Pharmacol Sci. 2015;2015:521718. doi: 10.1155/2015/521718. Epub 2015 Aug 02.

Comparative Effect of Lisinopril and Fosinopril in Mitigating Learning and Memory Deficit in Scopolamine-Induced Amnesic Rats.

Advances in pharmacological sciences

Debasree Deb, K L Bairy, Veena Nayak, Mohandas Rao

Affiliations

  1. Department of Pharmacology, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.
  2. Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal 576104, India.
  3. Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal Campus, Manipal 576104, India.

PMID: 26300914 PMCID: PMC4537708 DOI: 10.1155/2015/521718

Abstract

Lisinopril and fosinopril were compared on scopolamine-induced learning and memory deficits in rats. A total of eighty-four male Wistar rats were divided into seven groups. Group I received 2% gum acacia orally for 4 weeks, group II received normal saline, and group III received scopolamine (2 mg/kg/ip) as single dose. Groups IV and V received lisinopril ( 0.225 mg/kg and 0.45 mg/kg), while Groups VI and VII received fosinopril (0.90 mg/kg and 1.80 mg/kg), respectively, orally for four weeks, followed by scopolamine (2 mg/kg/ip) given 45 minutes prior to experimental procedure. Evaluation of learning and memory was assessed by using passive avoidance, Morris water maze, and elevated plus maze tests followed by analysis of hippocampal morphology and quantification of the number of surviving neurons. Scopolamine induced marked impairment of memory in behavioral tests which correlated with morphological changes in hippocampus. Pretreatment with fosinopril 1.80 mg/kg was found to significantly ameliorate the memory deficits and hippocampal degeneration induced by scopolamine. Fosinopril exhibits antiamnesic activity, indicating its possible role in preventing memory deficits seen in dementia though the precise mechanism underlying this effect needs to be further evaluated.

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