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Brunzell DH, Stafford AM, Dixon CI. Nicotinic receptor contributions to smoking: insights from human studies and animal models. Curr Addict Rep. 2015;2(1):33-46doi: 10.1007/s40429-015-0042-2.
Brunzell, D. H., Stafford, A. M., & Dixon, C. I. (2015). Nicotinic receptor contributions to smoking: insights from human studies and animal models. Current addiction reports, 2(1), 33-46. https://doi.org/10.1007/s40429-015-0042-2
Brunzell, Darlene H, et al. "Nicotinic receptor contributions to smoking: insights from human studies and animal models." Current addiction reports vol. 2,1 (2015): 33-46. doi: https://doi.org/10.1007/s40429-015-0042-2
Brunzell DH, Stafford AM, Dixon CI. Nicotinic receptor contributions to smoking: insights from human studies and animal models. Curr Addict Rep. 2015 Mar;2(1):33-46. doi: 10.1007/s40429-015-0042-2. PMID: 26301171; PMCID: PMC4540370.
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Curr Addict Rep. 2015 Mar;2(1):33-46. doi: 10.1007/s40429-015-0042-2.

Nicotinic receptor contributions to smoking: insights from human studies and animal models.

Current addiction reports

Darlene H Brunzell, Alexandra M Stafford, Claire I Dixon

Affiliations

  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA.

PMID: 26301171 PMCID: PMC4540370 DOI: 10.1007/s40429-015-0042-2

Abstract

It is becoming increasingly evident that a variety of factors contribute to smoking behavior. Nicotine is a constituent of tobacco smoke that exerts its psychoactive effects via binding to nicotinic acetylcholine receptors (nAChRs) in brain. Human genetic studies have identified polymorphisms in nAChR genes, which predict vulnerability to risk for tobacco dependence.

Keywords: acetylcholine; addiction; cholinergic; e-cigarettes; nicotine; tobacco

References

  1. Arch Gen Psychiatry. 2007 Sep;64(9):1078-86 - PubMed
  2. Mol Pharmacol. 2012 Apr;81(4):541-8 - PubMed
  3. Biol Psychiatry. 1997 Jul 1;42(1):1-5 - PubMed
  4. Pharmacol Biochem Behav. 2007 May;87(1):146-57 - PubMed
  5. Am J Med Genet. 2000 Oct 9;96(5):646-53 - PubMed
  6. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):596-604 - PubMed
  7. Ann N Y Acad Sci. 2014 Oct;1327:27-45 - PubMed
  8. J Neurosci. 2009 Mar 11;29(10):3014-8 - PubMed
  9. JAMA Psychiatry. 2014 Jul 1;71(7):797-805 - PubMed
  10. J Neurochem. 1988 Apr;50(4):1243-7 - PubMed
  11. Biol Psychiatry. 2011 Sep 15;70(6):528-36 - PubMed
  12. J Pharmacol Exp Ther. 2010 Aug;334(2):665-72 - PubMed
  13. JAMA. 2006 Jul 5;296(1):56-63 - PubMed
  14. J Neurosci. 2009 Feb 18;29(7):2272-82 - PubMed
  15. J Pharmacol Exp Ther. 2000 Mar;292(3):1053-64 - PubMed
  16. Addiction. 2008 Sep;103(9):1544-52 - PubMed
  17. Neuropharmacology. 2012 Nov;63(6):1002-11 - PubMed
  18. Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):421-9 - PubMed
  19. Nature. 1998 May 7;393(6680):76-9 - PubMed
  20. Addict Biol. 2010 Jul;15(3):346-57 - PubMed
  21. Am J Psychiatry. 1993 Dec;150(12):1856-61 - PubMed
  22. Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):926-33 - PubMed
  23. J Psychopharmacol. 2009 Sep;23(7):797-804 - PubMed
  24. J Pharmacol Exp Ther. 2014 May;349(2):348-54 - PubMed
  25. J Pharmacol Exp Ther. 2000 Sep;294(3):1112-9 - PubMed
  26. J Neurosci. 2010 Jul 21;30(29):9877-89 - PubMed
  27. J Mol Neurosci. 2010 Jan;40(1-2):185-95 - PubMed
  28. Hum Genet. 2014 May;133(5):575-86 - PubMed
  29. Psychopharmacology (Berl). 2006 Dec;189(3):395-401 - PubMed
  30. Hum Hered. 2004;57(2):59-68 - PubMed
  31. J Pharmacol Exp Ther. 2003 Nov;307(2):526-34 - PubMed
  32. Psychopharmacology (Berl). 2011 Sep;217(2):199-210 - PubMed
  33. Addict Behav. 2004 Feb;29(2):261-72 - PubMed
  34. J Neurochem. 2012 May;121(4):551-60 - PubMed
  35. Hum Mol Genet. 2009 Oct 15;18(20):4007-12 - PubMed
  36. Neuroreport. 1999 Jun 3;10(8):1779-82 - PubMed
  37. Neuropharmacology. 2004;47 Suppl 1:132-9 - PubMed
  38. Neuropharmacology. 2013 Jul;70:228-35 - PubMed
  39. Evid Based Med. 2013 Dec;18(6):212-3 - PubMed
  40. J Neurosci. 1998 Jun 15;18(12):4461-72 - PubMed
  41. Neuropsychopharmacology. 2013 Oct;38(11):2081-9 - PubMed
  42. Genes Brain Behav. 2010 Oct;9(7):741-50 - PubMed
  43. Neuropsychopharmacology. 2009 Feb;34(3):698-706 - PubMed
  44. Nicotine Tob Res. 2001 Nov;3(4):361-73 - PubMed
  45. J Neurosci. 2006 Aug 23;26(34):8707-14 - PubMed
  46. J Pharmacol Exp Ther. 2009 Nov;331(2):547-54 - PubMed
  47. J Neurosci. 2010 Apr 14;30(15):5311-25 - PubMed
  48. Psychopharmacology (Berl). 2012 Mar;220(1):1-14 - PubMed
  49. Psychopharmacology (Berl). 2013 Aug 20;:null - PubMed
  50. J Neurosci. 2001 Mar 15;21(6):1819-29 - PubMed
  51. J Neurosci. 2004 Nov 10;24(45):10035-9 - PubMed
  52. Mol Psychiatry. 2006 Mar;11(3):312-22, 223 - PubMed
  53. Pharmacol Biochem Behav. 2008 Sep;90(3):409-15 - PubMed
  54. J Natl Cancer Inst. 2012 May 16;104(10):740-8 - PubMed
  55. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3517-25 - PubMed
  56. Nat Genet. 2010 May;42(5):448-53 - PubMed
  57. J Biol Chem. 2012 Jul 20;287(30):25151-62 - PubMed
  58. Nicotine Tob Res. 2009 Mar;11(3):286-92 - PubMed
  59. Addict Behav. 2014 Jan;39(1):316-20 - PubMed
  60. Behav Brain Res. 2009 Jan 23;196(2):207-13 - PubMed
  61. Neuropharmacology. 2007 Dec;53(7):863-9 - PubMed
  62. Behav Genet. 2012 May;42(3):423-36 - PubMed
  63. J Pharmacol Exp Ther. 1997 Jul;282(1):7-13 - PubMed
  64. Neuropharmacology. 2003 Mar;44(3):367-73 - PubMed
  65. Psychopharmacology (Berl). 2006 Mar;184(3-4):339-44 - PubMed
  66. Mol Psychiatry. 2014 Aug;19(8):930-6 - PubMed
  67. Br J Addict. 1991 Sep;86(9):1119-27 - PubMed
  68. J Neurochem. 2014 May;129(4):721-31 - PubMed
  69. Arch Gen Psychiatry. 2006 Aug;63(8):907-15 - PubMed
  70. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2786-91 - PubMed
  71. Biol Psychiatry. 1991 Jul 15;30(2):109-15 - PubMed
  72. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2608-12 - PubMed
  73. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7577-82 - PubMed
  74. Neuropharmacology. 2013 Jul;70:35-42 - PubMed
  75. Pharmacol Biochem Behav. 1998 Jul;60(3):609-13 - PubMed
  76. JAMA. 2006 Jul 5;296(1):47-55 - PubMed
  77. Neuropsychopharmacology. 2012 Feb;37(3):641-50 - PubMed
  78. Neuropsychopharmacology. 2012 Apr;37(5):1134-43 - PubMed
  79. Hum Mol Genet. 2008 Mar 1;17(5):724-34 - PubMed
  80. J Neurosci. 2000 Sep 1;20(17 ):6431-41 - PubMed
  81. Nature. 2011 Mar 31;471(7340):597-601 - PubMed
  82. Nature. 2005 Jul 7;436(7047):103-7 - PubMed
  83. Mol Pharmacol. 2006 Sep;70(3):801-5 - PubMed
  84. Psychopharmacology (Berl). 1994 Jun;115(1-2):180-4 - PubMed
  85. J Pharmacol Exp Ther. 2014 Mar;348(3):410-20 - PubMed
  86. Nature. 2008 Apr 3;452(7187):638-42 - PubMed
  87. Science. 2004 Nov 5;306(5698):1029-32 - PubMed
  88. Respir Care. 2008 Sep;53(9):1217-22 - PubMed
  89. PLoS One. 2012;7(11):e48665 - PubMed
  90. Nicotine Tob Res. 2012 Nov;14(11):1346-55 - PubMed
  91. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):453-66 - PubMed
  92. Neuropsychopharmacology. 2015 Jan;40(2):350-60 - PubMed
  93. J Neurosci. 2013 May 1;33(18):7728-41 - PubMed
  94. Neuropsychiatr Dis Treat. 2008 Apr;4(2):353-63 - PubMed
  95. J Psychiatry Neurosci. 2007 Nov;32(6):412-6 - PubMed
  96. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):723-30 - PubMed
  97. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):587-92 - PubMed
  98. Neuropsychopharmacology. 2010 Feb;35(3):665-73 - PubMed
  99. J Neurosci. 2008 Nov 19;28(47):12318-27 - PubMed
  100. J Neurosci. 1993 Feb;13(2):596-604 - PubMed
  101. Br J Psychiatry. 2007 Nov;191:402-7 - PubMed
  102. J Nucl Med. 2007 Nov;48(11):1829-35 - PubMed
  103. J Neurosci. 2014 Jul 16;34(29):9789-802 - PubMed
  104. Hum Mol Genet. 2007 Jan 1;16(1):36-49 - PubMed
  105. Genomics. 1998 Sep 1;52(2):173-85 - PubMed
  106. Biol Psychiatry. 2004 Nov 1;56(9):657-64 - PubMed
  107. Nicotine Tob Res. 2002 Feb;4(1):115-25 - PubMed
  108. Genes Brain Behav. 2014 Feb;13(2):213-25 - PubMed
  109. Neuropsychopharmacology. 2008 Aug;33(9):2158-66 - PubMed
  110. Am J Hum Genet. 2004 Jul;75(1):112-21 - PubMed
  111. Nat Genet. 2010 May;42(5):436-40 - PubMed
  112. Biol Psychiatry. 2008 Jun 1;63(11):1039-46 - PubMed
  113. Nat Neurosci. 2001 Dec;4(12):1224-9 - PubMed
  114. J Neurosci. 2011 Jul 27;31(30):10891-902 - PubMed
  115. Nature. 1998 Jan 8;391(6663):173-7 - PubMed
  116. Genes Brain Behav. 2013 Apr;12(3):297-304 - PubMed
  117. J Neurosci. 2003 Jul 16;23(15):6255-63 - PubMed
  118. Arch Gen Psychiatry. 2009 Jun;66(6):666-76 - PubMed
  119. Mol Psychiatry. 2008 Apr;13(4):368-73 - PubMed
  120. Neuropsychopharmacology. 2004 Aug;29(8):1522-6 - PubMed
  121. Hum Mol Genet. 2008 Sep 15;17(18):2834-48 - PubMed
  122. JAMA. 2014 Jan 8;311(2):193-4 - PubMed
  123. J Neurosci. 1985 May;5(5):1307-15 - PubMed
  124. Psychopharmacology (Berl). 2006 Mar;184(3-4):328-38 - PubMed
  125. Addiction. 2014 May;109(5):814-22 - PubMed
  126. Am J Psychiatry. 2008 Sep;165(9):1163-71 - PubMed
  127. Eur J Neurosci. 2003 Apr;17 (7):1329-37 - PubMed
  128. Brain Res Mol Brain Res. 2002 Jan 31;98 (1-2):29-40 - PubMed
  129. Biol Psychiatry. 1992 Oct 1;32(7):607-16 - PubMed
  130. Eur J Pharmacol. 2005 May 23;516(1):40-5 - PubMed
  131. Biol Psychiatry. 1995 Jul 1;38(1):22-33 - PubMed
  132. Genes Brain Behav. 2011 Mar;10(2):176-85 - PubMed
  133. Neuropsychopharmacology. 2010 Nov;35(12):2392-402 - PubMed
  134. Brain Res. 1994 Aug 8;653(1-2):278-84 - PubMed
  135. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13509-14 - PubMed
  136. Am J Psychiatry. 1986 Aug;143(8):993-7 - PubMed
  137. Psychopharmacology (Berl). 2006 Aug;187(2):189-99 - PubMed
  138. Eur J Pharmacol. 2009 Mar 1;605(1-3):114-6 - PubMed
  139. J Pharmacol Exp Ther. 2002 Jul;302(1):197-204 - PubMed
  140. Neuropsychopharmacology. 2014 Jan;39(2):455-65 - PubMed
  141. J Pharmacol Exp Ther. 2009 Apr;329(1):377-86 - PubMed
  142. Hum Mol Genet. 2005 May 1;14(9):1211-9 - PubMed
  143. Neuron. 2008 Oct 9;60(1):123-36 - PubMed
  144. J Pharmacol Exp Ther. 2008 Apr;325(1):302-12 - PubMed
  145. Neuroreport. 2002 Jul 2;13(9):1097-106 - PubMed
  146. Neuron. 2011 May 12;70(3):522-35 - PubMed
  147. Genes Brain Behav. 2009 Apr;8(3):257-66 - PubMed

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