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J Community Hosp Intern Med Perspect. 2015 Sep 01;5(4):28374. doi: 10.3402/jchimp.v5.28374. eCollection 2015.

Autoimmune statin-induced myopathy: a case report.

Journal of community hospital internal medicine perspectives

Jonathan B Young, Ibrahim I Ghobrial

Affiliations

  1. Department of Medicine, UPMC McKeesport Hospital, McKeesport, PA, USA; [email protected].
  2. Department of Medicine, UPMC McKeesport Hospital, McKeesport, PA, USA.

PMID: 26333863 PMCID: PMC4558286 DOI: 10.3402/jchimp.v5.28374

Abstract

A 58-year-old woman with a history of statin use presented with a 4-month history of progressive weakness of both shoulders and thighs. Laboratory and electromyography testing confirmed the presence of generalized proximal myopathy and ruled out connective tissue disease, malignancy, or active viral infection. Muscle biopsy was consistent with necrotizing autoimmune myopathy.

Keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; antibody; autoimmune; necrotizing myopathy; statin

References

  1. Atherosclerosis. 2012 May;222(1):15-21 - PubMed
  2. JAMA. 2014 Feb 5;311(5):463-4 - PubMed
  3. Curr Opin Rheumatol. 2011 Nov;23(6):612-9 - PubMed
  4. N Engl J Med. 2014 Apr 10;370(15):1422-31 - PubMed
  5. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):484-93 - PubMed
  6. Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45 - PubMed
  7. Neuromuscul Disord. 2007 Feb;17(2):194-200 - PubMed
  8. Arthritis Rheum. 2011 Mar;63(3):713-21 - PubMed
  9. Curr Opin Rheumatol. 2013 Nov;25(6):747-52 - PubMed
  10. Mod Rheumatol. 2014 Sep;24(5):862-4 - PubMed
  11. Muscle Nerve. 2010 Feb;41(2):185-90 - PubMed
  12. Arthritis Rheum. 2010 Sep;62(9):2757-66 - PubMed

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