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Joukar S, Najafipour H, Mirzaeipour F, et al. Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury. EXCLI J. 2013;12:122-9
Joukar, S., Najafipour, H., Mirzaeipour, F., Nasri, H., Ahmadi, M. Y., & Badinloo, M. (2013). Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury. EXCLI journal, 12122-9.
Joukar, Siyavash, et al. "Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury." EXCLI journal vol. 12 (2013): 122-9.
Joukar S, Najafipour H, Mirzaeipour F, Nasri H, Ahmadi MY, Badinloo M. Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury. EXCLI J. 2013 Feb 19;12:122-9. eCollection 2013. PMID: 26417221; PMCID: PMC4531780.
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EXCLI J. 2013 Feb 19;12:122-9. eCollection 2013.

Modulatory effect of semelil (ANGIPARS™) on isoproterenol induced cardiac injury.

EXCLI journal

Siyavash Joukar, Hamid Najafipour, Fateme Mirzaeipour, Hamidreza Nasri, Mahboubeh Yeganeh Haj Ahmadi, Marziyeh Badinloo

Affiliations

  1. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Physiology and Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  2. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran ; Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  3. Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.

PMID: 26417221 PMCID: PMC4531780

Abstract

Administration of semelil (ANGIPARS™) has been successful in the treatment of diabetic foot ulcer. Considering the improvement of blood flow and anti-inflammatory effect that are attributed to this drug, we investigated its effect on cardiovascular performance in rabbits with isoproterenol (ISO) induced myocardial injury. Animal groups included: control group; ISO group, received ISO 50 mg/kg s.c. for two consecutive days; S1+ISO, S5+ISO and S10+ISO groups, received semelil 1, 5, and 10 mg/kg/day i.p. respectively, 30 min before ISO. On the 3(rd) day, electrocardiogram (ECG) and hemodynamic parameters were recorded; blood samples were taken and hearts were removed for lab investigations. ISO induced heart injury, ECG disturbance, raise of cardiac troponin I and significant decrease in LVSP (p<0.05), +dp/dt max (p<0.01), -dp/dt max (p<0.05) along with increase of LVEDP (p<0.01). Semelil had no significant effects on ECG and plasma cardiac troponin I. Impairment of +dp/dt max and -dp/dt max was significantly improved in S5+ISO and S10+ISO groups (P<0.05 versus ISO). In addition, LVSP and LVEDP was somewhat recovered in these groups, although semelil (1 mg/kg/day) to some extent exacerbated the myocardial lesions induced by ISO (P<0.05). Therefore, in stressful conditions, semelil may improve myocardial contractility; however, it may aggravate the severity of injury.

Keywords: arterial blood pressure; heart function; isoproterenol; myocardial injury; semelil

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