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Abdel-Salam OM, Salem NA, El-Sayed El-Shamarka M, et al. Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. EXCLI J. 2013;12:193-214
Abdel-Salam, O. M., Salem, N. A., El-Sayed El-Shamarka, M., Al-Said Ahmed, N., Seid Hussein, J., & El-Khyat, Z. A. (2013). Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. EXCLI journal, 12193-214.
Abdel-Salam, Omar M E, et al. "Cannabis-induced impairment of learning and memory: effect of different nootropic drugs." EXCLI journal vol. 12 (2013): 193-214.
Abdel-Salam OM, Salem NA, El-Sayed El-Shamarka M, Al-Said Ahmed N, Seid Hussein J, El-Khyat ZA. Cannabis-induced impairment of learning and memory: effect of different nootropic drugs. EXCLI J. 2013 Mar 12;12:193-214. eCollection 2013. PMID: 26417227; PMCID: PMC4552130.
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EXCLI J. 2013 Mar 12;12:193-214. eCollection 2013.

Cannabis-induced impairment of learning and memory: effect of different nootropic drugs.

EXCLI journal

Omar M E Abdel-Salam, Neveen A Salem, Marwa El-Sayed El-Shamarka, Noha Al-Said Ahmed, Jihan Seid Hussein, Zakaria A El-Khyat

Affiliations

  1. Department of Toxicology and Narcotics, National Research Centre, Cairo.
  2. Department of Medical Biochemistry, National Research Centre, Cairo.

PMID: 26417227 PMCID: PMC4552130

Abstract

Cannabis sativa preparations are the most commonly used illicit drugs worldwide. The present study aimed to investigate the effect of Cannabis sativa extract in the working memory version of the Morris water maze (MWM; Morris, 1984[43]) test and determine the effect of standard memory enhancing drugs. Cannabis sativa was given at doses of 5, 10 or 20 mg/kg (expressed as Δ(9)-tetrahydrocannabinol) alone or co-administered with donepezil (1 mg/kg), piracetam (150 mg/ kg), vinpocetine (1.5 mg/kg) or ginkgo biloba (25 mg/kg) once daily subcutaneously (s.c.) for one month. Mice were examined three times weekly for their ability to locate a submerged platform. Mice were euthanized 30 days after starting cannabis injection when biochemical assays were carried out. Malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide, glucose and brain monoamines were determined. Cannabis resulted in a significant increase in the time taken to locate the platform and enhanced the memory impairment produced by scopolamine. This effect of cannabis decreased by memory enhancing drugs with piracetam resulting in the most-shorter latency compared with the cannabis. Biochemically, cannabis altered the oxidative status of the brain with decreased MDA, increased GSH, but decreased nitric oxide and glucose. In cannabis-treated rats, the level of GSH in brain was increased after vinpocetine and donepezil and was markedly elevated after Ginkgo biloba. Piracetam restored the decrease in glucose and nitric oxide by cannabis. Cannabis caused dose-dependent increases of brain serotonin, noradrenaline and dopamine. After cannabis treatment, noradrenaline is restored to its normal value by donepezil, vinpocetine or Ginkgo biloba, but increased by piracetam. The level of dopamine was significantly reduced by piracetam, vinpocetine or Ginkgo biloba. These data indicate that cannabis administration is associated with impaired memory performance which is likely to involve decreased brain glucose availability as well as alterations in brain monoamine neurotransmitter levels. Piracetam is more effective in ameliorating the cognitive impairments than other nootropics by alleviating the alterations in glucose, nitric oxide and dopamine in brain.

Keywords: Cannabis sativa extract; brain monoamines; mice; nootropics, water maze; oxidative stress

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