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Hayami T, Kato Y, Kamiya H, et al. Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet. J Diabetes Investig. 2015;6(5):587-90doi: 10.1111/jdi.12330.
Hayami, T., Kato, Y., Kamiya, H., Kondo, M., Naito, E., Sugiura, Y., Kojima, C., Sato, S., Yamada, Y., Kasagi, R., Ando, T., Noda, S., Nakai, H., Takada, E., Asano, E., Motegi, M., Watarai, A., Kato, K., & Nakamura, J. (2015). Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet. Journal of diabetes investigation, 6(5), 587-90. https://doi.org/10.1111/jdi.12330
Hayami, Tomohide, et al. "Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet." Journal of diabetes investigation vol. 6,5 (2015): 587-90. doi: https://doi.org/10.1111/jdi.12330
Hayami T, Kato Y, Kamiya H, Kondo M, Naito E, Sugiura Y, Kojima C, Sato S, Yamada Y, Kasagi R, Ando T, Noda S, Nakai H, Takada E, Asano E, Motegi M, Watarai A, Kato K, Nakamura J. Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet. J Diabetes Investig. 2015 Sep;6(5):587-90. doi: 10.1111/jdi.12330. Epub 2015 Feb 20. PMID: 26417418; PMCID: PMC4578500.
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J Diabetes Investig. 2015 Sep;6(5):587-90. doi: 10.1111/jdi.12330. Epub 2015 Feb 20.

Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet.

Journal of diabetes investigation

Tomohide Hayami, Yoshiro Kato, Hideki Kamiya, Masaki Kondo, Ena Naito, Yukako Sugiura, Chika Kojima, Sami Sato, Yuichiro Yamada, Rina Kasagi, Toshihito Ando, Saeko Noda, Hiromi Nakai, Eriko Takada, Emi Asano, Mikio Motegi, Atsuko Watarai, Koichi Kato, Jiro Nakamura

Affiliations

  1. Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine Nagakute, Japan.
  2. Center for Preventive Medicine, Chubu Rosai Hospital Nagoya, Aichi, Japan.
  3. Laboratory of Medicine, Aichi Gakuin University School of Pharmacy Nagoya, Aichi, Japan.

PMID: 26417418 PMCID: PMC4578500 DOI: 10.1111/jdi.12330

Abstract

We present a case of a 32-year-old diabetic woman with Prader-Willi syndrome who developed severe ketoacidosis caused by a sodium-glucose cotransporter 2 (SGLT2) inhibitor, a novel class of antihyperglycemic agents, during a strict low-carbohydrate diet. At admission, a serum glucose level of 191 mg/dL was relatively low, though laboratory evaluations showed severe ketoacidosis. This is the first report of ketoacidosis caused by a SGLT2 inhibitor. It is necessary to not only pay attention when using a SGLT2 inhibitor in patients following a low-carbohydrate diet, but also to start a low-carbohydrate diet in patients treated with a SGLT2 inhibitor because of a high risk for developing ketoacidosis.

Keywords: Ketoacidosis; Low-carbohydrate diet; Sodium-glucose cotransporter 2 inhibitor

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