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J Clin Diagn Res. 2015 Jul;9(7):ED09-10. doi: 10.7860/JCDR/2015/12794.6218. Epub 2015 Jul 01.

Multicentric Metaplastic Breast Carcinoma with Squamous Differentiation.

Journal of clinical and diagnostic research : JCDR

Sunil Vitthalrao Jagtap, Suresh J Bhosale, P G Chougule, Shrutika D Dhawan, Dhiraj Shukla

Affiliations

  1. Professor, Department of Pathology, Krishna Institute of Medical Sciences University , Karad, Maharashtra, India .
  2. Professor, Department of Surgery, Krishna Institute of Medical Sciences University , Karad, Maharashtra, India .
  3. Assistant Lecturer, Department of Pathology, Krishna Institute of Medical Sciences University , Karad, Maharashtra, India .

PMID: 26393137 PMCID: PMC4572969 DOI: 10.7860/JCDR/2015/12794.6218

Abstract

Metaplastic breast carcinoma is a rare primary breast malignancy. A 45-year-old female patient presented with multicentric lumps in left breast of 6 months duration and history of axillary lymphadenopathy of 2 months duration. Mammography revealed two high density masses with ill defined margins. Fine needle aspiration cytology was positive for duct carcinoma cells. Histo pathologic examination, reported as "Multicentric infiltrating duct carcinoma with squamous differentiation left breast", grade 2. Immunohistochemistry revealed negativity for ER, PR and positivity for HER-2/neu. We are presenting this rare case for clinical, radiological, histopathological and immunohistochemical study.

Keywords: Histological subtype; Uncommon breast malignancies

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