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Rev Bras Reumatol. 2015 Jul 30; doi: 10.1016/j.rbr.2015.03.009. Epub 2015 Jul 30.

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Revista brasileira de reumatologia

[Article in Portuguese]
Anne E D Arraes, Alexandre W S de Souza, Henrique A Mariz, Neusa P Silva, Ivone C G Torres, Paula N V Pinto, Eduardo N P Lima, Emilia I Sato

Affiliations

  1. Disciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
  2. Divisão de Radiologia, Hospital A.C. Camargo, São Paulo, SP, Brasil.
  3. Disciplina de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil. Electronic address: [email protected].

PMID: 26304781 DOI: 10.1016/j.rbr.2015.03.009

Abstract

OBJECTIVE: To evaluate

METHODS: Serum levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-6, IL-8, IL-12, IL-18, MMP-3 and MMP-9 were measured in 36 TA patients and 36 controls. Maximum standard uptake value (SUV

RESULTS: Serum IL-6 and MMP-3 levels were higher in TA patients than in controls (p<0.001). Serum IL-6 was higher in patients with active disease and in patients with possible active disease than in inactive disease (p<0.0001). Patients with active disease had higher serum TNFα levels than patients with inactive disease (p=0.049) while patients with possible active disease presented higher IL-18 levels than patients with inactive disease (p=0.046). Patients with active disease had higher SUV

CONCLUSIONS: Higher serum IL-6 and TNFα levels as well as higher arterial 18F-FDG uptake are associated with active TA.

Copyright © 2015 Elsevier Editora Ltda. All rights reserved.

Keywords: Arterite de Takayasu; Citocinas; Cytokines; Matrix metalloproteinases; Metaloproteinases da matriz; Positron emission tomography scan; Takayasu's arteritis; Tomografia computadorizada

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