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Aparici CM, Win AZ. Lynch Syndrome Associated Colon Adenocarcinoma Resembling Lymphoma on Fluoro-Deoxyglucose-Positron Emission Tomography/Computed Tomography. World J Nucl Med. 2015;14(3):222-4doi: 10.4103/1450-1147.161728.
Aparici, C. M., & Win, A. Z. (2015). Lynch Syndrome Associated Colon Adenocarcinoma Resembling Lymphoma on Fluoro-Deoxyglucose-Positron Emission Tomography/Computed Tomography. World journal of nuclear medicine, 14(3), 222-4. https://doi.org/10.4103/1450-1147.161728
Aparici, Carina Mari, and Win, Aung Zaw. "Lynch Syndrome Associated Colon Adenocarcinoma Resembling Lymphoma on Fluoro-Deoxyglucose-Positron Emission Tomography/Computed Tomography." World journal of nuclear medicine vol. 14,3 (2015): 222-4. doi: https://doi.org/10.4103/1450-1147.161728
Aparici CM, Win AZ. Lynch Syndrome Associated Colon Adenocarcinoma Resembling Lymphoma on Fluoro-Deoxyglucose-Positron Emission Tomography/Computed Tomography. World J Nucl Med. 2015 Sep-Dec;14(3):222-4. doi: 10.4103/1450-1147.161728. PMID: 26420998; PMCID: PMC4564930.
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World J Nucl Med. 2015 Sep-Dec;14(3):222-4. doi: 10.4103/1450-1147.161728.

Lynch Syndrome Associated Colon Adenocarcinoma Resembling Lymphoma on Fluoro-Deoxyglucose-Positron Emission Tomography/Computed Tomography.

World journal of nuclear medicine

Carina Mari Aparici, Aung Zaw Win

Affiliations

  1. Department of Radiology, University of California, San Francisco, CA 94143, USA.
  2. Department of Radiology, San Francisco VA Medical Center, San Francisco, CA 94121, USA.

PMID: 26420998 PMCID: PMC4564930 DOI: 10.4103/1450-1147.161728

Abstract

The patient was a 46-year-old Asian male diagnosed with lynch syndrome associated colon adenocarcinoma in the right ascending colon. A presurgical staging 18-fluoro-deoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) found increased metabolic activity in the cervical, axillary, mediastinal, supraclavicular, para-aortic and mesenteric lymph nodes. This pattern of metastasis was very unusual for lynch syndrome associated colon adenocarcinoma and the involvement of those lymph nodes resembles the pattern of spread of lymphoma. He underwent right hemicolectomy and he was subsequently treated with 12 cycles of folinic acid (leucovorin), fluorouracil (5-FU), irinotecan. A restaging FDG-PET/CT at the end of the chemotherapy showed interval decrease in size and metabolic activity in the affected lymph nodes. FDG-PET/CT is a useful imaging modality in following-up the treatment response in colon adenocarcinoma.

Keywords: 18-fluoro-deoxyglucose-positron emission tomography/computed tomography; colon adenocarcinoma; lymph nodes; lymphoma; lynch syndrome

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