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Leight H, Zinn Z, Jalali O. Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris. Clin Cosmet Investig Dermatol. 2015;8:485-8doi: 10.2147/CCID.S89871.
Leight, H., Zinn, Z., & Jalali, O. (2015). Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris. Clinical, cosmetic and investigational dermatology, 8485-8. https://doi.org/10.2147/CCID.S89871
Leight, Hayley, et al. "Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris." Clinical, cosmetic and investigational dermatology vol. 8 (2015): 485-8. doi: https://doi.org/10.2147/CCID.S89871
Leight H, Zinn Z, Jalali O. Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris. Clin Cosmet Investig Dermatol. 2015 Sep 15;8:485-8. doi: 10.2147/CCID.S89871. eCollection 2015. PMID: 26396540; PMCID: PMC4576893.
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Clin Cosmet Investig Dermatol. 2015 Sep 15;8:485-8. doi: 10.2147/CCID.S89871. eCollection 2015.

Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris.

Clinical, cosmetic and investigational dermatology

Hayley Leight, Zachary Zinn, Omid Jalali

Affiliations

  1. Department of Dermatology, West Virginia University, Morgantown, WV, USA.

PMID: 26396540 PMCID: PMC4576893 DOI: 10.2147/CCID.S89871

Abstract

Here, we report a case of a middle-aged woman presenting with severe, long-standing, hyperkeratotic plaques of the lower extremities unrelieved by over-the-counter medications. Initial history and clinical findings were suggestive of an inherited ichthyosis. Ichthyoses are genetic disorders characterized by dry scaly skin and altered skin-barrier function. A diagnosis of ichthyosis vulgaris was confirmed by histopathology. Etiology, prevalence, and treatment options are discussed.

Keywords: FLG; filaggrin gene; hyperkeratosis; keratohyalin granules; profilaggrin

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