Opt Express. 2015 Jul 27;23(15):20104-14. doi: 10.1364/OE.23.020104.

Characteristic investigation of scanning surface plasmon microscopy for nucleotide functionalized nanoarray.

Optics express

Shih-Chung Wei, Pei-Tung Yang, Tzu-Heng Wu, Yin-Lin Lu, Frank Gu, Kung-Bin Sung, Chii-Wann Lin

PMID: 26367668 DOI: 10.1364/OE.23.020104

Abstract

A calculation based on surface plasmon coupling condition and Maxwell-Garnett equation was performed for predicting the coupling angle shift and thin film thickness in scanning surface plasmon microscopy (SSPM). The refractive index sensitivity and lateral resolution of an SSPM system was also investigated. The limit of detection of angle shift was 0.01°, the limit of quantification of angle shift was 0.03°, and the sensitivity was around 0.12° shift per nm ZnO film when the film thickness was less than 22.6 nm. Two partially connected Au nano-discs with a center-to-center distance of 1.1 μm could be identified as two peaks. The system was applied to image nanostructure defects and a virus-probe functionalized nanoarray. We expect the potential application in nanobiosensors with further optimization in the future.

Publication Types

• Journal Article