Display options
Cite
Sahu KK, Malhotra P, Khadwal A, et al. Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature. Indian J Hematol Blood Transfus. 2014;31(4):460-5doi: 10.1007/s12288-014-0436-7.
Sahu, K. K., Malhotra, P., Khadwal, A., Sachdeva, M. S., Sharma, P., Varma, N., & Varma, S. C. (2015). Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 31(4), 460-5. https://doi.org/10.1007/s12288-014-0436-7
Sahu, Kamal Kant, et al. "Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 31,4 (2015): 460-5. doi: https://doi.org/10.1007/s12288-014-0436-7
Sahu KK, Malhotra P, Khadwal A, Sachdeva MS, Sharma P, Varma N, Varma SC. Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature. Indian J Hematol Blood Transfus. 2015 Dec;31(4):460-5. doi: 10.1007/s12288-014-0436-7. Epub 2014 Jul 30. PMID: 26306071; PMCID: PMC4542759.
Copy Download .nbib Format: NLM
Share it on

Indian J Hematol Blood Transfus. 2015 Dec;31(4):460-5. doi: 10.1007/s12288-014-0436-7. Epub 2014 Jul 30.

Hypereosinophilia in Acute Lymphoblastic Leukemia: Two Cases with Review of Literature.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Kamal Kant Sahu, Pankaj Malhotra, Alka Khadwal, Manupdesh Singh Sachdeva, Prashant Sharma, Neelam Varma, Subhash Chander Varma

Affiliations

  1. Department of Clinical Hematology, Internal Medicine, PGIMER, Chandigarh, India.
  2. Department of Hepatopathology, PGIMER, Chandigarh, India.

PMID: 26306071 PMCID: PMC4542759 DOI: 10.1007/s12288-014-0436-7

Abstract

Eosinophilia is rare in acute leukemia at presentation. Discrete reports and case studies in recent years have created significant interest in the field of "Acute leukemia with eosinophilia". We herein present two cases of eosinophilia in association with acute lymphoblastic leukemia with brief review of literature in this field. First case is about 21-year-old female who presented with mediastinal mass along with leukocytosis and hypereosinophilia. On evaluation, she was found to have T cell acute lymphoblastic leukemia. After ruling out benign causes of eosinophilia, she was treated with modified BFM-90 protocol. Her eosinophilia resolved after 4 weeks of induction therapy. Second case is about 32-year-old male who was diagnosed as a case of mixed phenotype leukemia (B cell/myeloid type) along with severe eosinophilia. His hypereosinophilia finally resolved by week 16 of modified BFM-90 protocol. Diagnosing ALL is challenging when eosinophilia is the initial presentation. These two cases emphasize on the importance of considering ALL amongst one of the etiological causes of eosinophilia as delay in diagnosis endangers patient's life at risk. Also eosinophilia per se is an independent poor risk factor, hence prompt diagnosis and early treatment is the key in all such cases.

Keywords: Acute lymphoblastic leukemia; Eosinophilic pneumonia; Hypereosinophilia

References

  1. Keio J Med. 2010;59(2):64-8 - PubMed
  2. Br J Haematol. 2010 Jun;149(5):633 - PubMed
  3. Indian J Hematol Blood Transfus. 2013 Jun;29(2):113-5 - PubMed
  4. Blood. 2011 Aug 25;118(8):2239-42 - PubMed
  5. Leuk Lymphoma. 2007 Jul;48(7):1417-9 - PubMed
  6. J Hematol Oncol. 2009 Jun 21;2:26 - PubMed
  7. Acta Haematol. 2012;127(2):90-2 - PubMed
  8. Aging Clin Exp Res. 2012 Oct;24(5):555-8 - PubMed
  9. Pediatr Dev Pathol. 2003 Nov-Dec;6(6):558-63 - PubMed
  10. Am J Hematol. 2013 Nov;88(11):975 - PubMed
  11. Med Pediatr Oncol. 1984;12(1):33-7 - PubMed
  12. Chin J Cancer. 2012 Jan;31(1):45-50 - PubMed
  13. J Clin Oncol. 1987 Mar;5(3):382-90 - PubMed
  14. Nouv Presse Med. 1979 Feb 10;8(7):527 - PubMed
  15. Pediatr Neurol. 1992 Nov-Dec;8(6):466-8 - PubMed
  16. J Pediatr Hematol Oncol. 2013 May;35(4):303-6 - PubMed
  17. Arch Pathol Lab Med. 2003 May;127(5):601-5 - PubMed
  18. Zhonghua Yi Xue Za Zhi (Taipei). 1989 Apr;43(4):273-6 - PubMed
  19. Ugeskr Laeger. 2011 May 9;173(19):1363-4 - PubMed
  20. Acta Haematol. 1989;82(2):85-90 - PubMed
  21. Leuk Lymphoma. 2013 Aug;54(8):1788-90 - PubMed
  22. Am J Case Rep. 2013 May 08;14:143-6 - PubMed
  23. Acta Haematol. 2013;130(3):127-34 - PubMed
  24. Hum Pathol. 2014 Mar;45(3):643-7 - PubMed
  25. Medicine (Baltimore). 1990 Jul;69(4):232-43 - PubMed
  26. Aust Paediatr J. 1987 Dec;23(6):359-61 - PubMed
  27. J Pediatr Hematol Oncol. 2010 Aug;32(6):497-500 - PubMed
  28. Cancer Genet Cytogenet. 2010 Jan 1;196(1):105-8 - PubMed
  29. BMJ Case Rep. 2012 Jan 20;2012:null - PubMed
  30. Br Med Bull. 2007;81-82:115-27 - PubMed
  31. Iran J Pediatr. 2011 Dec;21(4):549-52 - PubMed
  32. Br J Haematol. 2012 Jun;157(5):517 - PubMed
  33. Blood. 1973 Sep;42(3):377-84 - PubMed

Publication Types