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Schlagnitweit J, Tang M, Baias M, et al. Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement. J Am Chem Soc. 2015;137(39):12482-5doi: 10.1021/jacs.5b08249.
Schlagnitweit, J., Tang, M., Baias, M., Richardson, S., Schantz, S., & Emsley, L. (2015). Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement. Journal of the American Chemical Society, 137(39), 12482-5. https://doi.org/10.1021/jacs.5b08249
Schlagnitweit, Judith, et al. "Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement." Journal of the American Chemical Society vol. 137,39 (2015): 12482-5. doi: https://doi.org/10.1021/jacs.5b08249
Schlagnitweit J, Tang M, Baias M, Richardson S, Schantz S, Emsley L. Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement. J Am Chem Soc. 2015 Oct 07;137(39):12482-5. doi: 10.1021/jacs.5b08249. Epub 2015 Sep 28. PMID: 26397956; PMCID: PMC4598824.
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J Am Chem Soc. 2015 Oct 07;137(39):12482-5. doi: 10.1021/jacs.5b08249. Epub 2015 Sep 28.

Nanostructure of Materials Determined by Relayed Paramagnetic Relaxation Enhancement.

Journal of the American Chemical Society

Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, Lyndon Emsley

Affiliations

  1. Institut de Science Analytiques, Centre de RMN à très hauts champs, Université de Lyon , CNRS/ENS de Lyon/UCB Lyon1, 69100 Villeurbanne, France.
  2. R&D Pharmaceutical Development, AstraZeneca , 431 50 Mölndal, Sweden.
  3. Institut des Sciences et Ingénierie Chimiques , Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

PMID: 26397956 PMCID: PMC4598824 DOI: 10.1021/jacs.5b08249

Abstract

Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm-μm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

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