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Rizzetto L, Weil T, Cavalieri D. Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection. Pathogens. 2015;4(3):639-61doi: 10.3390/pathogens4030639.
Rizzetto, L., Weil, T., & Cavalieri, D. (2015). Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection. Pathogens (Basel, Switzerland), 4(3), 639-61. https://doi.org/10.3390/pathogens4030639
Rizzetto, Lisa, et al. "Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection." Pathogens (Basel, Switzerland) vol. 4,3 (2015): 639-61. doi: https://doi.org/10.3390/pathogens4030639
Rizzetto L, Weil T, Cavalieri D. Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection. Pathogens. 2015 Aug 21;4(3):639-61. doi: 10.3390/pathogens4030639. PMID: 26308062; PMCID: PMC4584279.
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Pathogens. 2015 Aug 21;4(3):639-61. doi: 10.3390/pathogens4030639.

Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection.

Pathogens (Basel, Switzerland)

Lisa Rizzetto, Tobias Weil, Duccio Cavalieri

Affiliations

  1. Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. [email protected].
  2. Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. [email protected].
  3. Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all'Adige (TN) 38010, Italy. [email protected].
  4. Department of Neuroscience, Psychology, Drug Research and Child Health (Neurofarba), University of Florence, Firenze 50139, Italy. [email protected].

PMID: 26308062 PMCID: PMC4584279 DOI: 10.3390/pathogens4030639

Abstract

Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins' family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.

Keywords: C-type lectin receptors; Candida albicans; innate immunity; morphology; pathogen; yeast-hyphae

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