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Vedak TK, Ganwir V, Shah AB, et al. Vitamin D as a marker of cognitive decline in elderly Indian population. Ann Indian Acad Neurol. 2015;18(3):314-9doi: 10.4103/0972-2327.160052.
Vedak, T. K., Ganwir, V., Shah, A. B., Pinto, C., Lele, V. R., Subramanyam, A., Shah, H., & Deo, S. S. (2015). Vitamin D as a marker of cognitive decline in elderly Indian population. Annals of Indian Academy of Neurology, 18(3), 314-9. https://doi.org/10.4103/0972-2327.160052
Vedak, Tejal Kanhaiya, et al. "Vitamin D as a marker of cognitive decline in elderly Indian population." Annals of Indian Academy of Neurology vol. 18,3 (2015): 314-9. doi: https://doi.org/10.4103/0972-2327.160052
Vedak TK, Ganwir V, Shah AB, Pinto C, Lele VR, Subramanyam A, Shah H, Deo SS. Vitamin D as a marker of cognitive decline in elderly Indian population. Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):314-9. doi: 10.4103/0972-2327.160052. PMID: 26425010; PMCID: PMC4564467.
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Ann Indian Acad Neurol. 2015 Jul-Sep;18(3):314-9. doi: 10.4103/0972-2327.160052.

Vitamin D as a marker of cognitive decline in elderly Indian population.

Annals of Indian Academy of Neurology

Tejal Kanhaiya Vedak, Vaishali Ganwir, Arun B Shah, Charles Pinto, Vikram R Lele, Alka Subramanyam, Hina Shah, Sudha Shrikant Deo

Affiliations

  1. Ph.D. Student, Applied Biology (Immunology), Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  2. Clinical Psychologist, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  3. Consultant Neurologist, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  4. Emeritus Professor of Psychiatry, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  5. Director of Nuclear Medicine, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  6. Assistant Professor of Psychiatry, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  7. Junior Consultant, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.
  8. Senior Research Scientist and Co-PI, Sir H. N. Medical Research Society and Sir H. N. Reliance Foundation Hospital and Research Centre, Girgaum, Mumbai, Maharashtra, India.

PMID: 26425010 PMCID: PMC4564467 DOI: 10.4103/0972-2327.160052

Abstract

OBJECTIVES: Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population.

MATERIALS AND METHODS: The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH)D and total homocysteine were done.

RESULTS: Significant decreased concentration of 25(OH)D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls.

CONCLUSION: Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.

Keywords: Cognitive decline; MMSE score; dementia; homocysteine; vitamin D

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