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Liaw CC, Chang H, Yang TS, et al. Pulmonary Venous Obstruction in Cancer Patients. J Oncol. 2015;2015:210916doi: 10.1155/2015/210916.
Liaw, C. C., Chang, H., Yang, T. S., & Wen, M. S. (2015). Pulmonary Venous Obstruction in Cancer Patients. Journal of oncology, 2015210916. https://doi.org/10.1155/2015/210916
Liaw, Chuang-Chi, et al. "Pulmonary Venous Obstruction in Cancer Patients." Journal of oncology vol. 2015 (2015): 210916. doi: https://doi.org/10.1155/2015/210916
Liaw CC, Chang H, Yang TS, Wen MS. Pulmonary Venous Obstruction in Cancer Patients. J Oncol. 2015;2015:210916. doi: 10.1155/2015/210916. Epub 2015 Sep 06. PMID: 26425121; PMCID: PMC4575742.
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J Oncol. 2015;2015:210916. doi: 10.1155/2015/210916. Epub 2015 Sep 06.

Pulmonary Venous Obstruction in Cancer Patients.

Journal of oncology

Chuang-Chi Liaw, Hung Chang, Tsai-Sheng Yang, Ming-Sheng Wen

Affiliations

  1. Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.
  2. Division of Cardiology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan 33305, Taiwan.

PMID: 26425121 PMCID: PMC4575742 DOI: 10.1155/2015/210916

Abstract

Background. We study the clinical significance and management of pulmonary venous obstruction in cancer patients. Methods. We conducted a prospective cohort study to characterize the syndrome that we term "pulmonary vein obstruction syndrome" (PVOS) between January 2005 and March 2014. The criteria for inclusion were (1) episodes of shortness of breath; (2) chest X-ray showing abnormal pulmonary hilum shadow with or without presence of pulmonary edema and/or pleural effusion; (3) CT scan demonstrating pulmonary vein thrombosis/tumor with or without tumor around the vein. Results. Two hundred and twenty-two patients developed PVOS. Shortness of breath was the main symptom, which was aggravated by chemotherapy in 28 (13%), and medical/surgical procedures in 21 (9%) and showed diurnal change in intensity in 32 (14%). Chest X-rays all revealed abnormal pulmonary hilum shadows and presence of pulmonary edema in 194 (87%) and pleural effusion in 192 (86%). CT scans all showed pulmonary vein thrombosis/tumor (100%) and surrounding the pulmonary veins by tumor lesions in 140 patients (63%). PVOS was treated with low molecular weight heparin in combination with dexamethasone, and 66% of patients got clinical/image improvement. Conclusion. Physicians should be alert to PVOS when shortness of breath occurs and chest X-ray reveals abnormal pulmonary hilum shadows.

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