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Pan X, Wang X, Sun Y, et al. Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation. Int J Clin Exp Med. 2015;8(6):8720-9
Pan, X., Wang, X., Sun, Y., Dou, Z., & Li, Z. (2015). Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation. International journal of clinical and experimental medicine, 8(6), 8720-9.
Pan, Xiaoyan, et al. "Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation." International journal of clinical and experimental medicine vol. 8,6 (2015): 8720-9.
Pan X, Wang X, Sun Y, Dou Z, Li Z. Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation. Int J Clin Exp Med. 2015 Jun 15;8(6):8720-9. eCollection 2015. PMID: 26309523; PMCID: PMC4538079.
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Int J Clin Exp Med. 2015 Jun 15;8(6):8720-9. eCollection 2015.

Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation.

International journal of clinical and experimental medicine

Xiaoyan Pan, Xuenan Wang, Yanmei Sun, Zhaohua Dou, Zhixin Li

Affiliations

  1. Department of Histology and Embryology, Jilin Medical College Jilin, China.
  2. Reproductive Medicine Center of The Affiliated Hospital of Jining Medical College Jining, China.

PMID: 26309523 PMCID: PMC4538079

Abstract

The effect of preimplantation exposure to bisphenol-A (BPA) on blastocyst development and implantation is investigated. Mice were orally administered with BPA (200, 400, 600, and 800 mg/kg/day) from Day 0.5 to Day 3.5 of their pregnancy. Blastocyst development was examined on Day 4 of pregnancy. With 400 mg/kg/day BPA, implantation site number and implantation rate significantly reduced. With 600 and 800 mg/kg/day BPA, no implantation site was observed. BPA at 800 mg/kg/day significantly reduced blastocyst development rate and hatching rate. With 400 and 600 mg/kg/day BPA, Blastocyst development rate showed no significant difference whereas hatching rate was lower. With 400, 600, and 800 mg/kg/day BPA, some embryos were detected in the fallopian tube and hatched blastocysts showed greatly increased apoptosis level and endothelial nitric oxide synthase expression. In summary, high concentration BPA delayed the transfer of embryos to the uterus, damaged blastocyst development before implantation, and inhibited embryo implantation.

Keywords: Bisphenol A; apoptosis; blastocyst development; embryo implantation; endothelial nitric oxide synthase

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