Display options
Cite
Wu M, Zhu Y, Zhao J, et al. Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion. Int J Clin Exp Med. 2015;8(6):8812-9
Wu, M., Zhu, Y., Zhao, J., Ai, H., Gong, Q., Zhang, J., Zhao, J., Wang, Q., La, X., & Ding, J. (2015). Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion. International journal of clinical and experimental medicine, 8(6), 8812-9.
Wu, Mengru, et al. "Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion." International journal of clinical and experimental medicine vol. 8,6 (2015): 8812-9.
Wu M, Zhu Y, Zhao J, Ai H, Gong Q, Zhang J, Zhao J, Wang Q, La X, Ding J. Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion. Int J Clin Exp Med. 2015 Jun 15;8(6):8812-9. eCollection 2015. PMID: 26309533; PMCID: PMC4537953.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2015 Jun 15;8(6):8812-9. eCollection 2015.

Soluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortion.

International journal of clinical and experimental medicine

Mengru Wu, Yuejie Zhu, Jing Zhao, Haiquan Ai, Qiaoqiao Gong, Jia Zhang, Junda Zhao, Qingli Wang, Xiaoling La, Jianbing Ding

Affiliations

  1. Reproductive Medicine Center, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, Xinjiang, P. R. China.
  2. Reproductive Medicine Center, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, Xinjiang, P. R. China ; Department of Immunology, School of Preclinical Medicine of Xinjiang Medical University Urumqi 830011, Xinjiang, P. R. China.

PMID: 26309533 PMCID: PMC4537953

Abstract

This study is to investigate the mechanism of unexplained recurrent spontaneous abortion (URSA). A total of 35 cases of URSA patients (URSA group), 20 cases with normal pregnancy (normal pregnancy group) and 20 healthy non-pregnancy candidates (healthy control group) were enrolled in this study. Enzyme linked immunosorbent assay (ELISA) method was used for detection of serum soluble Tim-3 (sTim3) and Galectin-9. Cytokine bead array (CBA) determination method was used to detect IFN-γ and IL-4 expression levels. Compared with the healthy control group, sTim-3 levels in normal pregnancy group and URSA group increased, and URSA group had significantly higher sTim-3 levels than normal pregnancy group (P < 0.05). Compared with the healthy control group, Galectin-9 levels in normal pregnancy group and URSA group also increased. However, the normal pregnancy group had significantly higher Galectin-9 level than URSA group (P < 0.05). IFN-γ levels in normal pregnancy group and URSA group were lower than those in healthy control group, and IFN-γ levels in the normal pregnancy group were significantly lower than those in URSA group (P < 0.05). Levels of IL-4 in normal pregnancy group and URSA groups increased compared with the healthy control group, and the IL-4 levels in normal pregnancy group were significantly higher than those in URSA group (P < 0.05). Th1/Th2 imbalance, sTim-3 and Galectin-9 expression increase are found in the patients with URSA, ant this might be involved in the regulation of immunity in pregnancy.

Keywords: IFN-γ; IL-4; galectin-9; sTim-3; unexplained recurrent spontaneous abortion

References

  1. Am J Reprod Immunol. 2012 Apr;67(4):304-10 - PubMed
  2. Trends Endocrinol Metab. 2012 Jan;23(1):23-31 - PubMed
  3. PLoS One. 2014 Mar 20;9(3):e92371 - PubMed
  4. Reprod Biol Endocrinol. 2013 Nov 11;11:104 - PubMed
  5. J Reprod Immunol. 2014 Jun;103:9-17 - PubMed
  6. Nat Immunol. 2009 Jul;10(7):706-12 - PubMed
  7. J Reprod Immunol. 2013 Mar;97(1):36-42 - PubMed
  8. J Obstet Gynaecol Res. 2008 Feb;34(1):7-11 - PubMed
  9. J Immunol. 2013 May 15;190(10 ):4991-9 - PubMed
  10. PLoS One. 2012;7(2):e30676 - PubMed
  11. J Ethnopharmacol. 2013 Jan 9;145(1):241-53 - PubMed
  12. Clin Chim Acta. 2011 Apr 11;412(9-10):702-8 - PubMed
  13. J Immunol. 2012 Jul 15;189(2):755-66 - PubMed
  14. J Immunol. 2013 Jan 1;190(1):88-96 - PubMed
  15. Stem Cells Dev. 2014 Apr 1;23(7):755-66 - PubMed
  16. Reprod Biol Endocrinol. 2014 Aug 03;12:74 - PubMed
  17. Genes Immun. 2011 Dec;12(8):595-604 - PubMed
  18. Am J Reprod Immunol. 2010 Jun;63(6):601-10 - PubMed
  19. Reprod Biomed Online. 2014 Oct;29(4):481-9 - PubMed
  20. J Huazhong Univ Sci Technolog Med Sci. 2014 Aug;34(4):586-90 - PubMed
  21. Eur J Obstet Gynecol Reprod Biol. 2012 Dec;165(2):326-30 - PubMed
  22. J Immunol. 2010 Aug 1;185(3):1383-92 - PubMed
  23. J Immunol. 2009 May 15;182(10 ):6618-24 - PubMed
  24. Hum Reprod. 2011 Nov;26(11):2964-71 - PubMed
  25. Int J Fertil Steril. 2014 Apr;8(1):59-66 - PubMed
  26. Blood. 2008 Sep 1;112(5):1557-69 - PubMed
  27. ISRN Obstet Gynecol. 2012;2012:512732 - PubMed
  28. Annu Rev Immunol. 2010;28:445-89 - PubMed
  29. Hum Reprod. 2012 Jul;27(7):1882-6 - PubMed

Publication Types