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Xue J, Yu H, Yan J, et al. Non-Epstein-Barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review. Int J Clin Exp Med. 2015;8(6):10051-7
Xue, J., Yu, H., Yan, J., Ren, N., Yang, Y., Wang, X., & Wang, Y. (2015). Non-Epstein-Barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review. International journal of clinical and experimental medicine, 8(6), 10051-7.
Xue, Jinru, et al. "Non-Epstein-Barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review." International journal of clinical and experimental medicine vol. 8,6 (2015): 10051-7.
Xue J, Yu H, Yan J, Ren N, Yang Y, Wang X, Wang Y. Non-Epstein-Barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review. Int J Clin Exp Med. 2015 Jun 15;8(6):10051-7. eCollection 2015. PMID: 26309699; PMCID: PMC4538029.
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Int J Clin Exp Med. 2015 Jun 15;8(6):10051-7. eCollection 2015.

Non-Epstein-Barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review.

International journal of clinical and experimental medicine

Jinru Xue, Haixin Yu, Jidong Yan, Na Ren, Yi Yang, Xueju Wang, Yan Wang

Affiliations

  1. Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University Changchun 130033, China.
  2. Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University Changchun 130033, China.
  3. Department of Pathology, China-Japan Union Hospital of Jilin University Changchun 130033, China.

PMID: 26309699 PMCID: PMC4538029

Abstract

A 55-year-old Chinese male was admitted to the hospital for epigastralgia and dysphagia with a two month history, and hematemesis and melena with a two-day history. Two lesions were found in the esophagus and stomach by esophago--gastroduodenoscopy and computed tomography. The patient underwent subtotal esophagectomy and gastrectomy, esophagogastric anastomosis above the aortic arch, and thoracic-abdominal two-field lymph node dissection. Pathological and immumohistochemical studies showed that both lesions had the same form of poorly differentiated carcinoma with dense lymphoid stroma, which was diagnosed as lymphoepithelioma-like carcinoma (LELC). No metastatic relationship was found between the two tumors. Therefore, the case was double primary lymphoepithelioma-like carcinoma of the esophagus and stomach. Epstein-Barr virus (EBV) in the two tumors were negative by EBV-encoded small RNA1 (EBER-1) in situ hybridization. No adjuvant therapy was performed due to his poor physical condition post-operatively, and no evidence of tumor recurrence or metastasis was found during the next 14 months of follow-up. Esophageal and gastric LELC are rare, especially the former, which has a specific geographical distribution. Literature reported cases showed upper gastrointestinal LELC were highly malignant with good prognosis, and EBV was detected less in esophageal LELC cases but more commonly in gastric LELC cases. Upper gastrointestinal LELC lesions are usually singular, and no synchronous lesions were reported in the literature. Our case is the first LELC to present as double primary lymphoepithelioma- like carcinoma of both esophagus and stomach simultaneously, which demonstrates that LELC can be multifocal in the upper gastrointestinal tract.

Keywords: Esophagus; diagnosis; double primary; lymphoepithelioma-like carcinoma; stomach

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