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Yasar Z, Kirakli C, Cimen P, et al. Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?. Int J Clin Exp Med. 2015;8(6):10114-21
Yasar, Z., Kirakli, C., Cimen, P., Ucar, Z. Z., Talay, F., & Tibet, G. (2015). Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?. International journal of clinical and experimental medicine, 8(6), 10114-21.
Yasar, Zehra, et al. "Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?." International journal of clinical and experimental medicine vol. 8,6 (2015): 10114-21.
Yasar Z, Kirakli C, Cimen P, Ucar ZZ, Talay F, Tibet G. Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?. Int J Clin Exp Med. 2015 Jun 15;8(6):10114-21. eCollection 2015. PMID: 26309710; PMCID: PMC4538104.
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Int J Clin Exp Med. 2015 Jun 15;8(6):10114-21. eCollection 2015.

Is non-thyroidal illness syndrome a predictor for prolonged weaning in intubated chronic obstructive pulmonary disease patients?.

International journal of clinical and experimental medicine

Zehra Yasar, Cenk Kirakli, Pınar Cimen, Zeynep Zeren Ucar, Fahrettin Talay, Gultekin Tibet

Affiliations

  1. Department of Chest Diseases, Abant Izzet Baysal University School of Medicine Bolu, Turkey.
  2. Pulmonary Division, Dr. Suat Seren Chest Diseases and Surgery Teaching and Research Hospital Izmir, Turkey.

PMID: 26309710 PMCID: PMC4538104

Abstract

INTRODUCTION: Non-thyroidal illness syndrome (NTIS) is considered to be associated with adverse outcomes in intensive care unit (ICU) patients. In this study, we evaluated the association between NTIS and prolonged weaning in chronic obstructive pulmonary disease (COPD) patients admitted to the ICU.

MATERIALS AND METHODS: In total, 125 patients with COPD admitted to our ICU who underwent invasive mechanical ventilation (MV) were enrolled. We collected each patient's baseline characteristics including Acute Physiology and Chronic Health Evaluation (APACHE) II score, body mass index (BMI), and thyroid hormones 24 h after ICU admission. The presence of pulmonary infection was also recorded. The primary outcome was prolonged weaning, defined as patients who failed at least three weaning attempts or required > 7 days of weaning after the first spontaneous breathing trial.

RESULTS: Of the 127 patients studied, 64 had normal thyroid function tests and 61 had NTIS. Patients with NTIS had significantly higher APACHE II scores, prolonged weaning, and pulmonary infection. Patients with NTIS had a higher risk for prolonged weaning (odds ratio, OR = 3.21; 95% CI = 1.31-7.83).The presence of pulmonary infection was also an independent risk factors for prolonged weaning.

CONCLUSIONS: NTIS may be an independent predictor for prolonged weaning in intubated COPD patients.

Keywords: COPD; ICU; NTIS; prolonged weaning

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