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Sallustio F, Serino G, Schena FP. Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury. Biores Open Access. 2015;4(1):326-33doi: 10.1089/biores.2015.0011.
Sallustio, F., Serino, G., & Schena, F. P. (2015). Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury. BioResearch open access, 4(1), 326-33. https://doi.org/10.1089/biores.2015.0011
Sallustio, Fabio, et al. "Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury." BioResearch open access vol. 4,1 (2015): 326-33. doi: https://doi.org/10.1089/biores.2015.0011
Sallustio F, Serino G, Schena FP. Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury. Biores Open Access. 2015 Jul 01;4(1):326-33. doi: 10.1089/biores.2015.0011. eCollection 2015. PMID: 26309808; PMCID: PMC4509615.
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Biores Open Access. 2015 Jul 01;4(1):326-33. doi: 10.1089/biores.2015.0011. eCollection 2015.

Potential Reparative Role of Resident Adult Renal Stem/Progenitor Cells in Acute Kidney Injury.

BioResearch open access

Fabio Sallustio, Grazia Serino, Francesco Paolo Schena

Affiliations

  1. Department of Emergency and Organ Transplantation, University of Bari , Bari, Italy . ; C.A.R.S.O. Consortium, Strada Prov. le Valenzano-Casamassima Km 3 , Valenzano, Italy . ; Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento , Lecce-Monteroni, Lecce, Italy .
  2. Department of Emergency and Organ Transplantation, University of Bari , Bari, Italy .
  3. C.A.R.S.O. Consortium, Strada Prov. le Valenzano-Casamassima Km 3 , Valenzano, Italy . ; Schena Foundation, Research Center of Renal Diseases , Bari, Italy .

PMID: 26309808 PMCID: PMC4509615 DOI: 10.1089/biores.2015.0011

Abstract

Human kidney is particularly susceptible to ischemia and toxins with consequential tubular necrosis and activation of inflammatory processes. This process can lead to the acute renal injury, and even if the kidney has a great capacity for regeneration after tubular damage, in several circumstances, the normal renal repair program may not be sufficient to achieve a successful regeneration. Resident adult renal stem/progenitor cells could participate in this repair process and have the potentiality to enhance the renal regenerative mechanism. This could be achieved both directly, by means of their capacity to differentiate and integrate into the renal tissues, and by means of paracrine factors able to induce or improve the renal repair or regeneration. Recent genetic fate-tracing studies indicated that tubular damage is instead repaired by proliferative duplication of epithelial cells, acquiring a transient progenitor phenotype and by fate-restricted clonal cell progeny emerging from different nephron segments. In this review, we discuss about the properties and the reparative characteristics of high regenerative CD133(+)/CD24(+) cells, with a view to a future application of these cells for the treatment of acute renal injury.

Keywords: acute kidney injury; regenerative medicine; renal progenitor cells; toll-like receptors

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