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J Investig Med High Impact Case Rep. 2014 Jul 16;2(3):2324709614543691. doi: 10.1177/2324709614543691. eCollection 2014.

Follicular Thyroid Carcinoma Presenting With Endobronchial Metastases: Case Report and Review of Literature.

Journal of investigative medicine high impact case reports

Nduche Chika Onyeaso, Aidar R Gosmanov

Affiliations

  1. University of Tennessee Health Science Center, Memphis, TN, USA.

PMID: 26425617 PMCID: PMC4528904 DOI: 10.1177/2324709614543691

Abstract

Endobronchial metastasis is a rare manifestation of differentiated thyroid cancer. A 79-year-old male was admitted to the hospital with shortness of breath, chest pain, anemia, and weight loss. Computed tomography of chest revealed multiple lung nodules. Bronchoscopy showed an endobronchial lesion in the right upper lobe. The biopsy of the lesion demonstrated neoplastic cells stained positive for thyroglobulin, thyroid transcription factor-1, and cytokeratin-7, consistent with metastatic follicular thyroid cancer. Physical examination revealed a firm fixed thyroid nodule, which was confirmed by thyroid ultrasound. He subsequently underwent total thyroidectomy and neck exploration. Thyroid gland pathology revealed a nodule with features of high-grade follicular thyroid carcinoma. Metastatic thyroid cancer should be considered in workup of pulmonary nodules. We recommend an examination of thyroid gland in patients who present with pulmonary nodules associated with signs and symptoms of malignancy.

Keywords: endobronchial metastases; follicular thyroid cancer

References

  1. Chest. 2001 Mar;119(3):768-75 - PubMed
  2. Hum Pathol. 1990 Mar;21(3):283-90 - PubMed
  3. J Natl Med Assoc. 2006 May;98(5):803-6 - PubMed
  4. J Cancer Res Ther. 2008 Jan-Mar;4(1):44-5 - PubMed
  5. Thyroid. 2009 Nov;19(11):1167-214 - PubMed
  6. Intern Med. 2012;51(4):401-3 - PubMed
  7. Thyroid. 2011 Jul;21(7):751-7 - PubMed
  8. Cancer. 2005 Jun 1;103(11):2269-73 - PubMed
  9. J Clin Endocrinol Metab. 1991 Oct;73(4):832-6 - PubMed
  10. Respir Med. 2000 Apr;94(4):369-72 - PubMed

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