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Simões ER, Santos EA, de Abreu MC, et al. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol. 2015;4(3):256-63doi: 10.5455/jice.20150610104841.
Simões, E. R., Santos, E. A., de Abreu, M. C., Silva, J. d. o. . N., Nunes, N. M., da Costa, M. P., Pessoa, O. D., Pessoa, C., & Ferreira, P. M. (2015). Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. Journal of intercultural ethnopharmacology, 4(3), 256-63. https://doi.org/10.5455/jice.20150610104841
Simões, Evelyne Rolim Braun, et al. "Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils." Journal of intercultural ethnopharmacology vol. 4,3 (2015): 256-63. doi: https://doi.org/10.5455/jice.20150610104841
Simões ER, Santos EA, de Abreu MC, Silva Jdo N, Nunes NM, da Costa MP, Pessoa OD, Pessoa C, Ferreira PM. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):256-63. doi: 10.5455/jice.20150610104841. Epub 2015 Jun 26. PMID: 26401417; PMCID: PMC4579491.
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J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):256-63. doi: 10.5455/jice.20150610104841. Epub 2015 Jun 26.

Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils.

Journal of intercultural ethnopharmacology

Evelyne Rolim Braun Simões, Evelyne Alves Santos, Maria Carolina de Abreu, Jurandy do Nascimento Silva, Nárcia Mariana Fonseca Nunes, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, Paulo Michel Pinheiro Ferreira

Affiliations

  1. Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
  2. Departamento de Ciências Biológicas, Campus Senador Helvídio Nunes de Barros, Universidade Federal do Piauí, Picos, Piauí, Brasil.
  3. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil.
  4. Departamento de Química Orgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
  5. Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil ; Fundação Oswaldo Cruz, Fortaleza, Ceará, Brasil.
  6. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina, Piauí, Brasil ; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, Teresina, Piauí, Brasil.

PMID: 26401417 PMCID: PMC4579491 DOI: 10.5455/jice.20150610104841

Abstract

Lippia microphylla Cham. (Verbenaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (vantage point 7.1) associated with Derwent Innovation Index was used to identify the indicators of the genus Lippia, and biological activities and compounds in the L. macrophylla species. Ethnopharmacological records report use of L. microphylla leaves to treat gastrointestinal disorders, influenza, bronchitis, cough, nasal congestion, and sinusitis during vaporization, whose aromatic volatile oils are rich in monoterpenes, especially cineole, terpineol, and thymol. Other EOs have larvicidal activity on Aedes aegypti larvae, and antifungal, antibacterial and cytotoxic and antitumor action on human and murine cancer cells. Brazil is the country with more articles about Lippia species, but it deposited only 9 patents since 1993. Most of the publications about L. microphylla are concentrated in food and chemical sciences. This bioprospection helps to choice areas of interest for capital investment and to give support for Brazilian Institutions to establish cooperation and improve technological impact at the point of view of creation and innovation.

Keywords: Antitumor action; Lippia microphylla; pharmacological activity; scientific indicators; terpenes

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