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Capuano A, Sullo MG, Rafaniello C, et al. Complete resistance after maximal dose of rocuronium. J Pharmacol Pharmacother. 2015;6(3):175-8doi: 10.4103/0976-500X.162012.
Capuano, A., Sullo, M. G., Rafaniello, C., Sportiello, L., Fusco, P., De Vizia, M., & Ferraro, F. (2015). Complete resistance after maximal dose of rocuronium. Journal of pharmacology & pharmacotherapeutics, 6(3), 175-8. https://doi.org/10.4103/0976-500X.162012
Capuano, Annalisa, et al. "Complete resistance after maximal dose of rocuronium." Journal of pharmacology & pharmacotherapeutics vol. 6,3 (2015): 175-8. doi: https://doi.org/10.4103/0976-500X.162012
Capuano A, Sullo MG, Rafaniello C, Sportiello L, Fusco P, De Vizia M, Ferraro F. Complete resistance after maximal dose of rocuronium. J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):175-8. doi: 10.4103/0976-500X.162012. PMID: 26312006; PMCID: PMC4544144.
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J Pharmacol Pharmacother. 2015 Jul-Sep;6(3):175-8. doi: 10.4103/0976-500X.162012.

Complete resistance after maximal dose of rocuronium.

Journal of pharmacology & pharmacotherapeutics

Annalisa Capuano, Maria Giuseppa Sullo, Concetta Rafaniello, Liberata Sportiello, Pierfrancesco Fusco, Macella De Vizia, Fausto Ferraro

Affiliations

  1. Department of Experimental Medicine, Section of Pharmacology, Pharmacoepidemiology and Pharmacovigilance Center of the Campania Region, Second University of Naples, Caserta, Italy.
  2. Department of Anesthesia and Intensive Care, San Salvatore Hospital, L'Aquila, Italy.
  3. Department of Anesthetic, Surgical, and Emergency Science - Intensive Care Unit, Second University of Naples, Naples, Caserta, Italy.

PMID: 26312006 PMCID: PMC4544144 DOI: 10.4103/0976-500X.162012

Abstract

Rocuronium is a non-depolarizing neuromuscular blocking agent (NDNMBA), employed in the clinic as an adjunct to general anesthesia to facilitate tracheal intubation rapid sequence, and to provide skeletal muscle relaxation during surgery. Many cases of resistance to neuromuscular blocking agents (NMBAs) have been anecdotally reported. There are specific pathologic states, such as upper motor neuron lesions, severe thermal injuries, liver disease, renal failure, disuse atrophy, all of which show an increased resistance to the effects of nondepolarizing muscle relaxants. Also concurrent drug therapy can alter the efficacy of NMBAs such as some classes of antibiotics, furosemide, β receptor agonists, phosphodiesterase inhibitors, calcium antagonists, respiratory stimulants but also ketamine, propofol and barbiturates at high concentrations. In this scenario we describe an unusual case of 20-years-old man who showed a complete resistance to rocuronium maybe due to a glucocorticoids concomitant therapy.

Keywords: Drug therapeutic failure; glucocorticoids; neuromuscular block; rocuronium

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