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Bronkhorst MW, Patka P, Lieshout EM. Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes. Open Orthop J. 2015;9:367-71doi: 10.2174/1874325001509010367.
Bronkhorst, M. W., Patka, P., & Lieshout, E. M. (2015). Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes. The open orthopaedics journal, 9367-71. https://doi.org/10.2174/1874325001509010367
Bronkhorst, Maarten W G A, et al. "Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes." The open orthopaedics journal vol. 9 (2015): 367-71. doi: https://doi.org/10.2174/1874325001509010367
Bronkhorst MW, Patka P, Lieshout EM. Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes. Open Orthop J. 2015 Jul 31;9:367-71. doi: 10.2174/1874325001509010367. eCollection 2015. PMID: 26312121; PMCID: PMC4541467.
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Open Orthop J. 2015 Jul 31;9:367-71. doi: 10.2174/1874325001509010367. eCollection 2015.

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes.

The open orthopaedics journal

Maarten W G A Bronkhorst, Peter Patka, Esther M M Van Lieshout

Affiliations

  1. Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  2. Department of Accident & Emergency, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

PMID: 26312121 PMCID: PMC4541467 DOI: 10.2174/1874325001509010367

Abstract

Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma patient with multiple infectious complications caused by multiple micro-organisms leading to prolonged hospital stay with numerous treatments. This patient had multiple single nucleotide polymorphisms (SNPs) in the MBL2, MASP2, FCN2 and TLR2 genes, most likely contributing to increased susceptibility and severity of infectious disease.

Keywords: Complications; genetic variation; infection; multiple organ dysfunction syndrome; single nucleotide polymorphism; systemic inflammatory response syndrome; trauma.

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