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Ventura Aguiar P, Dias C, Azevedo P, et al. Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient. J Nephropathol. 2015;4(3):97-100doi: 10.12860/jnp.2015.18.
Ventura Aguiar, P., Dias, C., Azevedo, P., Silva, H. N., Almeida, M., Pedroso, S., Martins, L. S., Dias, L., Rodrigues, A., Viscaíño, R., Cabrita, A., & Henriques, A. C. (2015). Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient. Journal of nephropathology, 4(3), 97-100. https://doi.org/10.12860/jnp.2015.18
Ventura Aguiar, Pedro, et al. "Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient." Journal of nephropathology vol. 4,3 (2015): 97-100. doi: https://doi.org/10.12860/jnp.2015.18
Ventura Aguiar P, Dias C, Azevedo P, Silva HN, Almeida M, Pedroso S, Martins LS, Dias L, Rodrigues A, Viscaíño R, Cabrita A, Henriques AC. Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient. J Nephropathol. 2015 Jul;4(3):97-100. doi: 10.12860/jnp.2015.18. Epub 2015 Jul 01. PMID: 26312238; PMCID: PMC4544561.
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J Nephropathol. 2015 Jul;4(3):97-100. doi: 10.12860/jnp.2015.18. Epub 2015 Jul 01.

Histiocytic sarcoma; case report of a rare disease in a kidney transplant recipient.

Journal of nephropathology

Pedro Ventura Aguiar, Carla Dias, Pedro Azevedo, Hugo Neves Silva, Manuela Almeida, Sofia Pedroso, La Salete Martins, Leonídio Dias, Anabela Rodrigues, Ramón Viscaíño, António Cabrita, António Castro Henriques

Affiliations

  1. Renal Transplant Unit, Nephrology Department, Centro Hospitalar do Porto, Portugal.
  2. Department of Pathology, Centro Hospitalar do Porto, Portugal.

PMID: 26312238 PMCID: PMC4544561 DOI: 10.12860/jnp.2015.18

Abstract

BACKGROUND: Histiocytic sarcoma (HS) is a rare hematologic neoplasm with a few hundred cases having been described to date.

CASE PRESENTATION: We report the case of a 56-year-old woman with a history of hepatitis C infection and chronic kidney disease (CKD), submitted to a kidney transplant in 1984, under maintenance immunosuppression with prednisone and azathioprine. Patient presented with a relentlessly growing mass on her right front thorax. It was painless, smooth, and adherent to the deep muscle. Laboratory studies were unremarkable. Ultrasonography and computerized tomography (CT) scan revealed a highly vascularized heterogeneous mass (8×9 cm), with a necrotic centre. Positron emission tomography (PET) scan demonstrated multiple thoracic, abdominal, and pelvic nodules. Histology revealed a highly undifferentiated HS (vimentin, CD68, CD99, and CD4 positive). In spite of having started treatment with etoposide and thalidomide, no clinical response was achieved and the patient died three months later.

CONCLUSIONS: To the authors' knowledge, this is the first described case of HS in a solid organ transplant patient.

Keywords: Chronic kidney disease; Histiocytic sarcoma; Malignancy; Post-transplant lymphoproliferative disease; Transplant

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