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Fu MR, Axelrod D, Guth AA, et al. Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study. J Pers Med. 2015;5(3):326-40doi: 10.3390/jpm5030326.
Fu, M. R., Axelrod, D., Guth, A. A., Fletcher, J., Qiu, J. M., Scagliola, J., Kleinman, R., Ryan, C. E., Chan, N., & Haber, J. (2015). Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study. Journal of personalized medicine, 5(3), 326-40. https://doi.org/10.3390/jpm5030326
Fu, Mei R, et al. "Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study." Journal of personalized medicine vol. 5,3 (2015): 326-40. doi: https://doi.org/10.3390/jpm5030326
Fu MR, Axelrod D, Guth AA, Fletcher J, Qiu JM, Scagliola J, Kleinman R, Ryan CE, Chan N, Haber J. Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study. J Pers Med. 2015 Sep 03;5(3):326-40. doi: 10.3390/jpm5030326. PMID: 26404383; PMCID: PMC4600151.
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J Pers Med. 2015 Sep 03;5(3):326-40. doi: 10.3390/jpm5030326.

Patterns of Obesity and Lymph Fluid Level during the First Year of Breast Cancer Treatment: A Prospective Study.

Journal of personalized medicine

Mei R Fu, Deborah Axelrod, Amber A Guth, Jason Fletcher, Jeanna M Qiu, Joan Scagliola, Robin Kleinman, Caitlin E Ryan, Nicholas Chan, Judith Haber

Affiliations

  1. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].
  2. Department of Surgery, School of Medicine, New York University, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  3. NYU Laura and Isaac Perlmutter Cancer Center, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  4. Department of Surgery, School of Medicine, New York University, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  5. NYU Laura and Isaac Perlmutter Cancer Center, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  6. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].
  7. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].
  8. NYU Laura and Isaac Perlmutter Cancer Center, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  9. NYU Laura and Isaac Perlmutter Cancer Center, 160 East 34 Street, New York, NY 10016, USA. [email protected].
  10. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].
  11. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].
  12. College of Nursing, New York University, 433 First Avenue, New York, NY 10010, USA. [email protected].

PMID: 26404383 PMCID: PMC4600151 DOI: 10.3390/jpm5030326

Abstract

Obesity is one of the risk factors for developing lymphedema following breast cancer treatment. We prospectively enrolled 140 women and followed the participants for 12 months after surgery to investigate patterns of obesity and lymph fluid level in the first year of cancer treatment. Electrical bioimpedance devices were used to measure weight, BMI, and percent of body fat as well as lymph fluid level. General instructions were given to the participants on maintaining pre-surgery weight. Among the 140 participants, 136 completed the study with 2.9% attrition. More than 60% of the participants were obese (30.8%) or overweight (32.4%), while only two participants were underweight and about 35% had normal weight. This pattern of obesity and overweight was consistent at 4-8 weeks and 12 months post-surgery. At 12 months post-surgery, the majority of the women (72.1%) maintained pre-surgery weight and 15.4% had >5% weight loss; 12.5% of the women increase >5% of their weight. Significantly more patients in the obesity group had lymphedema defined by L-Dex ratio >7.1 than those in the normal/underweight and overweight group at pre-surgery and 4-8 weeks post-surgery. There was a trend of more patients in the obesity group had L-Dex ratio >7.1 at 12 months post-surgery. Obesity and overweight remain among women at the time of cancer diagnosis and the patterns of obesity and overweight continue during the first year of treatment. General instructions on having nutrition-balanced and portion-appropriate diet and physical activities daily or weekly can be effective to maintain pre-surgery weight.

Keywords: body mass index; breast cancer; lymph fluid; lymphedema; obesity; overweight

References

  1. World J Clin Oncol. 2014 Aug 10;5(3):241-7 - PubMed
  2. Lymphology. 2009 Dec;42(4):161-75 - PubMed
  3. J Clin Oncol. 2008 Nov 10;26(32):5213-9 - PubMed
  4. Mol Clin Oncol. 2014 Jan;2(1):105-110 - PubMed
  5. Nutr Cancer. 2011;63(4):538-48 - PubMed
  6. Support Care Cancer. 2011 Jun;19(6):853-7 - PubMed
  7. Breast J. 2010 Jan-Feb;16(1):48-54 - PubMed
  8. Breast Cancer Res Treat. 2010 Aug;122(3):823-33 - PubMed
  9. Arch Surg. 2010 Nov;145(11):1055-63 - PubMed
  10. Clin J Oncol Nurs. 2014;18 Suppl:68-79 - PubMed
  11. World J Clin Oncol. 2014 Aug 10;5(3):272-82 - PubMed
  12. Lancet Oncol. 2013 May;14(6):500-15 - PubMed
  13. Ann Surg Oncol. 2014 Oct;21(11):3481-9 - PubMed
  14. Asian Pac J Cancer Prev. 2010;11(6):1535-40 - PubMed
  15. Cancer. 2012 Apr 15;118(8 Suppl):2277-87 - PubMed
  16. Breast Cancer Res Treat. 2013 Nov;142(1):59-67 - PubMed
  17. Lymphology. 2013 Jun;46(2):85-96 - PubMed
  18. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):775-82 - PubMed
  19. Cancer Causes Control. 2010 Apr;21(4):621-9 - PubMed
  20. Australas Radiol. 2006 Dec;50(6):578-82 - PubMed
  21. Cancer. 2001 Sep 15;92(6):1368-77 - PubMed
  22. Ann Oncol. 2014 Oct;25(10):1901-14 - PubMed
  23. Ann Surg Oncol. 2010 Dec;17(12):3278-86 - PubMed
  24. Ann Oncol. 2013 Oct;24(10 ):2506-14 - PubMed
  25. J Clin Oncol. 2005 Feb 1;23(4):774-82 - PubMed
  26. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  27. J Clin Oncol. 2009 Apr 20;27(12):2007-14 - PubMed
  28. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2734-46 - PubMed
  29. Ann Surg Oncol. 2009 Jul;16(7):1959-72 - PubMed

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