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Ahmed N, Brahmbhatt KG, Khan SI, et al. Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities. Chem Biol Drug Des. 2012;doi: 10.1111/j.1747-0285.2012.01427.x.
Ahmed, N., Brahmbhatt, K. G., Khan, S. I., Jacob, M., Tekwani, B. L., Sabde, S., Mitra, D., Singh, I. P., Khan, I. A., & Bhutani, K. K. (2012). Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities. Chemical biology & drug design, . https://doi.org/10.1111/j.1747-0285.2012.01427.x
Ahmed, Nafees, et al. "Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities." Chemical biology & drug design vol. (2012). doi: https://doi.org/10.1111/j.1747-0285.2012.01427.x
Ahmed N, Brahmbhatt KG, Khan SI, Jacob M, Tekwani BL, Sabde S, Mitra D, Singh IP, Khan IA, Bhutani KK. Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities. Chem Biol Drug Des. 2012 Jun 15; doi: 10.1111/j.1747-0285.2012.01427.x. Epub 2012 Jun 15. PMID: 26404724.
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Chem Biol Drug Des. 2012 Jun 15; doi: 10.1111/j.1747-0285.2012.01427.x. Epub 2012 Jun 15.

Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal and anti-HIV activities.

Chemical biology & drug design

Nafees Ahmed, Keyur G Brahmbhatt, Shabana I Khan, Melissa Jacob, Babu L Tekwani, Sudeep Sabde, Debashis Mitra, Inder Pal Singh, Ikhlas A Khan, Kamlesh K Bhutani

Affiliations

  1. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, Punjab-160062, IndiaNational Center for Natural Products ResearchDepartment of PharmacognosyDepartment of Pharmacology, School of Pharmacy, University of Mississippi, MS 38677, USANational Center for Cell Science (NCCS), Pune University Campus, Ganeshkhind, Pune, Maharashtra-411007, India.

PMID: 26404724 DOI: 10.1111/j.1747-0285.2012.01427.x

Abstract

Fifty analogues of batzelladine K were synthesized and evaluated for in vitro antimalarial (Plasmodium falciparum), antileishmanial (Leishmania donovani), antimicrobial (panel of bacteria and fungi), antiviral (HIV-1) activities. Analogues 14h and 20l exhibited potential antimalarial activity against chloroquine-sensitive D6 strain with IC

© 2012 John Wiley & Sons A/S.

Keywords: Batzelladine; antileishmanial; antimalarial; antimicrobial; anti‐HIV; tricyclic guanidine

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