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Gruner M, van der Linden AM. Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors. Worm. 2015;4(2):e1023497doi: 10.1080/21624054.2015.1023497.
Gruner, M., & van der Linden, A. M. (2015). Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors. Worm, 4(2), e1023497. https://doi.org/10.1080/21624054.2015.1023497
Gruner, Matthew, and van der Linden, Alexander M. "Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors." Worm vol. 4,2 (2015): e1023497. doi: https://doi.org/10.1080/21624054.2015.1023497
Gruner M, van der Linden AM. Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors. Worm. 2015 Mar 06;4(2):e1023497. doi: 10.1080/21624054.2015.1023497. eCollection 2015. PMID: 26430563; PMCID: PMC4588537.
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Worm. 2015 Mar 06;4(2):e1023497. doi: 10.1080/21624054.2015.1023497. eCollection 2015.

Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors.

Worm

Matthew Gruner, Alexander M van der Linden

Affiliations

  1. Department of Biology; University of Nevada ; Reno, NV USA.

PMID: 26430563 PMCID: PMC4588537 DOI: 10.1080/21624054.2015.1023497

Abstract

Animals dramatically modify their chemosensory behaviors when starved, which could allow them to alter and optimize their food-search strategies. Dynamic changes in the gene expression of chemoreceptors may be a general mechanism underlying food and state-dependent changes in chemosensory behaviors. In our recent study,(1) we identified chemoreceptors in the ADL sensory neuron type of C. elegans that are modulated by feeding state and food availability. Here, we highllight our recent findings by which sensory inputs into ADL, neuronal outputs from ADL, and circuit inputs from the RMG interneuron, which is electrically connected to ADL, are required to regulate an ADL-expressed chemoreceptor. This sensory and circuit-mediated regulation of chemoreceptor gene expression is dependent on cell-autonomous pathways acting in ADL, e.g. KIN-29, DAF-2, OCR-2 and calcium signaling, and circuit inputs from RMG mediated by NPR-1. Based on these findings, we propose an intriguing but speculative feedback modulatory circuit mechanism by which sensory perception of food and internal state signals may be coupled to regulate ADL-expressed chemoreceptors, which may allow animals to precisely regulate and fine-tune their chemosensory neuron responses as a function of feeding state.

Keywords: ADL; chemoreceptor; feeding state; food; gene regulation; neural circuit; plasticity; sensory input; sensory neuron

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