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Deebukkhum S, Pingmuangkaew P, Tangvarasittichai O, et al. Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients. Indian J Clin Biochem. 2012;27(3):239-45doi: 10.1007/s12291-012-0192-0.
Deebukkhum, S., Pingmuangkaew, P., Tangvarasittichai, O., & Tangvarasittichai, S. (2012). Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients. Indian journal of clinical biochemistry : IJCB, 27(3), 239-45. https://doi.org/10.1007/s12291-012-0192-0
Deebukkhum, Suwipar, et al. "Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients." Indian journal of clinical biochemistry : IJCB vol. 27,3 (2012): 239-45. doi: https://doi.org/10.1007/s12291-012-0192-0
Deebukkhum S, Pingmuangkaew P, Tangvarasittichai O, Tangvarasittichai S. Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients. Indian J Clin Biochem. 2012 Jul;27(3):239-45. doi: 10.1007/s12291-012-0192-0. Epub 2012 Mar 28. PMID: 26405381; PMCID: PMC4577509.
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Indian J Clin Biochem. 2012 Jul;27(3):239-45. doi: 10.1007/s12291-012-0192-0. Epub 2012 Mar 28.

Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients.

Indian journal of clinical biochemistry : IJCB

Suwipar Deebukkhum, Patchanrin Pingmuangkaew, Orathai Tangvarasittichai, Surapon Tangvarasittichai

Affiliations

  1. Chronic Disease Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand 65000.
  2. Department of Community Occupational Family Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.

PMID: 26405381 PMCID: PMC4577509 DOI: 10.1007/s12291-012-0192-0

Abstract

Type 2 diabetes mellitus (T2D) patients are increased risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). Many studies had demonstrated that CKD is significantly associated with CVD. We aim to indicate the using estimated creatinine clearance (eCrCl), homocysteine (tHcy), and high sensitivity-C-reactive protein (hs-CRP) levels, may have an impact on the interpretation risk for nephropathy and CVD. eCrCl was using the Cockroft-Gault formula, eCrCl levels were stratified according to the Kidney Disease Outcome Quality Initiative definition. We measured serum tHcy, hs-CRP, and the other biochemical variables in 54 T2D patients compared with 40 age matched healthy controls (NDM). T2D patients were significantly lower eCrCl than NDM (P < 0.05). T2D patients also showed significantly higher in tHcy, hs-CRP, and MDA levels than NDM subjects (P < 0.05). The eCrCl was significantly correlated with tHcy and hs-CRP levels in T2D patients (r = -0.504, P < 0.001; r = -0.282, P = 0.047). eCrCl had an impact on interpretation for CKD, especially in T2D patients. Decrease eCrCl concomitant with increased in tHcy, hs-CRP, and MDA levels may present a higher risk for future diabetic nephropathy and CVD.

Keywords: Cardiovascular disease; Chronic kidney disease; Estimated creatinine clearance; Homocysteine; Hs-CRP; Type 2 diabetes mellitus

References

  1. Clin Chem. 1972 Jun;18(6):499-502 - PubMed
  2. Ann Intern Med. 2001 Apr 17;134(8):629-36 - PubMed
  3. Diabetes Care. 2002 Oct;25(10):1813-7 - PubMed
  4. Ann Intern Med. 1999 Sep 7;131(5):363-75 - PubMed
  5. Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266 - PubMed
  6. Kidney Int. 1999 Mar;55(3):1028-35 - PubMed
  7. Diabetes. 2006 Jun;55(6):1832-9 - PubMed
  8. JAMA. 2001 Jul 4;286(1):64-70 - PubMed
  9. Nat Med. 2003 Jun;9(6):641-2 - PubMed
  10. Circulation. 1998 May 26;97(20):2007-11 - PubMed
  11. J Inherit Metab Dis. 1997 Jun;20(2):301-6 - PubMed
  12. Curr Control Trials Cardiovasc Med. 2000;1(2):98-101 - PubMed
  13. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):3071-8 - PubMed
  14. Diabetes Care. 1999 Jan;22(1):125-32 - PubMed
  15. Am J Cardiol. 2001 Jul 15;88(2):112-7 - PubMed
  16. J Am Coll Cardiol. 2001 Oct;38(4):955-62 - PubMed
  17. Nephron. 1976;16(1):31-41 - PubMed
  18. Circ Res. 1999 Jul 9;85(1):108-16 - PubMed
  19. Kidney Int Suppl. 2003 May;(84):S131-3 - PubMed
  20. Atherosclerosis. 1995 Jul;116(1):59-62 - PubMed
  21. Diabet Med. 1995 Feb;12(2):149-55 - PubMed
  22. Rheumatology (Oxford). 1999 Jun;38(6):529-34 - PubMed
  23. N Engl J Med. 1999 Jan 14;340(2):115-26 - PubMed
  24. JAMA. 1998 Feb 4;279(5):359-64 - PubMed
  25. Kidney Int. 1987 May;31(5):1153-9 - PubMed
  26. JAMA. 1997 Jun 11;277(22):1775-81 - PubMed
  27. Diabetes Care. 1993 Feb;16(2):434-44 - PubMed
  28. Diabetes. 2002 Apr;51(4):1157-65 - PubMed

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