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Benish-Weisman M, Kerem E, Knafo-Noam A, et al. The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors. Front Psychiatry. 2015;6:109doi: 10.3389/fpsyt.2015.00109.
Benish-Weisman, M., Kerem, E., Knafo-Noam, A., & Belsky, J. (2015). The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors. Frontiers in psychiatry, 6109. https://doi.org/10.3389/fpsyt.2015.00109
Benish-Weisman, Maya, et al. "The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors." Frontiers in psychiatry vol. 6 (2015): 109. doi: https://doi.org/10.3389/fpsyt.2015.00109
Benish-Weisman M, Kerem E, Knafo-Noam A, Belsky J. The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors. Front Psychiatry. 2015 Aug 17;6:109. doi: 10.3389/fpsyt.2015.00109. eCollection 2015. PMID: 26347661; PMCID: PMC4538223.
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Front Psychiatry. 2015 Aug 17;6:109. doi: 10.3389/fpsyt.2015.00109. eCollection 2015.

The Moderating Role of Genetics: The Effect of Length of Hospitalization on Children's Internalizing and Externalizing Behaviors.

Frontiers in psychiatry

Maya Benish-Weisman, Eitan Kerem, Ariel Knafo-Noam, Jay Belsky

Affiliations

  1. Department of Counseling and Human Development, University of Haifa , Haifa , Israel.
  2. Division of Pediatrics, Hadassah Hospital , Jerusalem , Israel.
  3. Department of Psychology, The Hebrew University of Jerusalem , Jerusalem , Israel.
  4. Department of Human Ecology, University of California Davis , Davis, CA , USA.

PMID: 26347661 PMCID: PMC4538223 DOI: 10.3389/fpsyt.2015.00109

Abstract

The study considered individual differences in children's ability to adjust to hospitalization and found the length of hospitalization to be related to adaptive psychological functioning for some children. Applying the theoretical framework of three competing models of gene-X-environment interactions (diathesis-stress, differential susceptibility, and vantage sensitivity), the study examined the moderating effect of genetics (DRD4) on the relationship between the length of hospitalization and internalizing and externalizing problems. Mothers reported on children's hospitalization background and conduct problems (externalizing) and emotional symptoms (internalizing), using subscales of the 25-item Strength and Difficulties Questionnaire (1). Data on both hospitalization and genetics were available for 65 children, 57% of whom were females, with an average age of 61.4 months (SD = 2.3). The study found length of hospitalization did not predict emotional and behavior problems per se, but the interaction with genetics was significant; the length of hospitalization was related to diminished levels of internalizing and externalizing problems only for children with the 7R allele (the sensitive variant). The vantage sensitivity model best accounted for how the length of hospitalization and genetics related to children's internalizing and externalizing problems.

Keywords: DRD4; behavioral problems; emotional problems; externalizing behavior; gene–environment interaction; hospitalization; internalizing behavior; length of hospitalization

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