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Noujaim J, Thway K, Bajwa Z, et al. Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy. Front Oncol. 2015;5:186doi: 10.3389/fonc.2015.00186.
Noujaim, J., Thway, K., Bajwa, Z., Bajwa, A., Maki, R. G., Jones, R. L., & Keller, C. (2015). Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy. Frontiers in oncology, 5186. https://doi.org/10.3389/fonc.2015.00186
Noujaim, Jonathan, et al. "Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy." Frontiers in oncology vol. 5 (2015): 186. doi: https://doi.org/10.3389/fonc.2015.00186
Noujaim J, Thway K, Bajwa Z, Bajwa A, Maki RG, Jones RL, Keller C. Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy. Front Oncol. 2015 Aug 17;5:186. doi: 10.3389/fonc.2015.00186. eCollection 2015. PMID: 26347853; PMCID: PMC4538302.
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Front Oncol. 2015 Aug 17;5:186. doi: 10.3389/fonc.2015.00186. eCollection 2015.

Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy.

Frontiers in oncology

Jonathan Noujaim, Khin Thway, Zia Bajwa, Ayeza Bajwa, Robert G Maki, Robin L Jones, Charles Keller

Affiliations

  1. Royal Marsden Hospital , London , UK.
  2. Children's Cancer Therapy Development Institute , Fort Collins, CO , USA.
  3. Adult and Paediatric Sarcoma Program, Tisch Cancer Institute, Mount Sinai School of Medicine , New York, NY , USA.

PMID: 26347853 PMCID: PMC4538302 DOI: 10.3389/fonc.2015.00186

Abstract

Epithelioid sarcoma (ES) is a soft tissue sarcoma of children and young adults for which the preferred treatment for localized disease is wide surgical resection. Medical management is to a great extent undefined, and therefore for patients with regional and distal metastases, the development of targeted therapies is greatly desired. In this review, we will summarize clinically relevant biomarkers (e.g., SMARCB1, CA125, dysadherin, and others) with respect to targeted therapeutic opportunities. We will also examine the role of EGFR, mTOR, and polykinase inhibitors (e.g., sunitinib) in the management of local and disseminated disease. Toward building a consortium of pharmaceutical, academic, and non-profit collaborators, we will discuss the state of resources for investigating ES with respect to cell line resources, tissue banks, and registries so that a roadmap can be developed toward effective biology-driven therapies.

Keywords: BAF47; INI1; SMARCB1; SWI/SNF complex; epithelioid sarcoma

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