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Stafstrom CE, Benke TA. Autism and Epilepsy: Exploring the Relationship Using Experimental Models. Epilepsy Curr. 2015;15(4):206-10doi: 10.5698/1535-7511-15.4.206.
Stafstrom, C. E., & Benke, T. A. (2015). Autism and Epilepsy: Exploring the Relationship Using Experimental Models. Epilepsy currents, 15(4), 206-10. https://doi.org/10.5698/1535-7511-15.4.206
Stafstrom, Carl E, and Benke, Tim A. "Autism and Epilepsy: Exploring the Relationship Using Experimental Models." Epilepsy currents vol. 15,4 (2015): 206-10. doi: https://doi.org/10.5698/1535-7511-15.4.206
Stafstrom CE, Benke TA. Autism and Epilepsy: Exploring the Relationship Using Experimental Models. Epilepsy Curr. 2015 Jul-Aug;15(4):206-10. doi: 10.5698/1535-7511-15.4.206. PMID: 26316869; PMCID: PMC4532234.
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Epilepsy Curr. 2015 Jul-Aug;15(4):206-10. doi: 10.5698/1535-7511-15.4.206.

Autism and Epilepsy: Exploring the Relationship Using Experimental Models.

Epilepsy currents

Carl E Stafstrom, Tim A Benke

Affiliations

  1. Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
  2. Division of Pediatric Neurology, University of Colorado, School of Medicine, Children's Hospital Colorado, Aurora, CO.

PMID: 26316869 PMCID: PMC4532234 DOI: 10.5698/1535-7511-15.4.206

Abstract

The common co-occurrence of autism and epilepsy suggests that certain neurobiological mechanisms are shared between these disorders. In particular, the profusion of novel genetic mutations being discovered in autism and epilepsy points to abnormalities in synapse formation and function that alter the balance between neuronal excitation and inhibition. Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them. As mechanistic information accrues, it is anticipated that mutation- and pathway-specific targeted treatments can be developed.

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