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Fuoco D, di Tomasso J, Boulos C, et al. Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients. Ecancermedicalscience. 2015;9:561doi: 10.3332/ecancer.2015.561.
Fuoco, D., di Tomasso, J., Boulos, C., Kilgour, R. D., Morais, J. A., Borod, M., & Vigano, A. (2015). Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients. Ecancermedicalscience, 9561. https://doi.org/10.3332/ecancer.2015.561
Fuoco, Domenico, et al. "Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients." Ecancermedicalscience vol. 9 (2015): 561. doi: https://doi.org/10.3332/ecancer.2015.561
Fuoco D, di Tomasso J, Boulos C, Kilgour RD, Morais JA, Borod M, Vigano A. Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients. Ecancermedicalscience. 2015 Aug 04;9:561. doi: 10.3332/ecancer.2015.561. eCollection 2015. PMID: 26316882; PMCID: PMC4544574.
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Ecancermedicalscience. 2015 Aug 04;9:561. doi: 10.3332/ecancer.2015.561. eCollection 2015.

Identifying nutritional, functional, and quality of life correlates with male hypogonadism in advanced cancer patients.

Ecancermedicalscience

Domenico Fuoco, Jonathan di Tomasso, Caroline Boulos, Robert D Kilgour, Jose A Morais, Manuel Borod, Antonio Vigano

Affiliations

  1. McGill Nutrition and Performance Laboratory, McGill University Health Centre, Montreal H4A 3S5, Canada ; Division of Supportive and Palliative Care Medicine, McGill University Health Centre, Montreal H4A 3S5, Canada.
  2. Division of Supportive and Palliative Care Medicine, McGill University Health Centre, Montreal H4A 3S5, Canada.
  3. McGill Nutrition and Performance Laboratory, McGill University Health Centre, Montreal H4A 3S5, Canada.
  4. McGill Nutrition and Performance Laboratory, McGill University Health Centre, Montreal H4A 3S5, Canada ; Department of Exercise Science, Concordia University, Montreal H4B 1R6, Canada.
  5. McGill Nutrition and Performance Laboratory, McGill University Health Centre, Montreal H4A 3S5, Canada ; Department of Geriatric Medicine, McGill University, Montreal H4A 3S5, Canada.

PMID: 26316882 PMCID: PMC4544574 DOI: 10.3332/ecancer.2015.561

Abstract

With the availability of a potential treatment to reverse male hypogonadism (MH), the primary aim of this case series study was to determine independent relationships between this condition and the nutritional, functional, and quality of life characteristics of advanced cancer patients (ACP). Free testosterone levels were measured in 100 male patients with advanced lung and gastrointestinal (GI) cancer. Routine blood markers of nutrition and inflammation, self-reporting questionnaires for symptom, nutrition, and functional status along with handgrip dynamometry were assessed for all patients at bedside. Almost half of this cohort underwent further assessments (body composition, lower body strength, in depth quality of life and fatigue questionnaires) at the McGill Nutrition and Performance Laboratory (mnupal.mcgill.ca). Multiple regression analyses were performed to identify independent correlations between free testosterone and the above measures. Seventy-six percent of patients were diagnosed with MH. Using multiple linear regression, low free testosterone (31.2 pmol/L) was independently associated with lower albumin (B = -3.8 g/L; 95% confidence interval CI -6.8:-0.8), muscle strength (-11.7 lbs; -20.4: -3.0) and mass in upper limbs (-0.8 kg; -1.4: -0.1), overall performance status (Eastern Cooperative Oncology Group Performance Scale, ECOG PS 0.6; 0.1:1.1), cancer-related fatigue (Brief Fatigue Inventory, BFI 16.7; 2.0: 31.3), and overall quality of life (MQoL total score -1.42; -2.5: -0.3). Thus MH seems to be highly prevalent in ACP, and it is independently associated with important nutritional, functional, and quality of life characteristics in this patient population.

Keywords: cachexia; cancer; case series study; function; hypogonadism; male; quality of life; testosterone

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