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Selvakumar K, Bavithra S, Suganya S, et al. Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats. J Biomark. 2012;2013:960125doi: 10.1155/2013/960125.
Selvakumar, K., Bavithra, S., Suganya, S., Ahmad Bhat, F., Krishnamoorthy, G., & Arunakaran, J. (2013). Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats. Journal of biomarkers, 2013960125. https://doi.org/10.1155/2013/960125
Selvakumar, Kandaswamy, et al. "Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats." Journal of biomarkers vol. 2013 (2013): 960125. doi: https://doi.org/10.1155/2013/960125
Selvakumar K, Bavithra S, Suganya S, Ahmad Bhat F, Krishnamoorthy G, Arunakaran J. Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats. J Biomark. 2013;2013:960125. doi: 10.1155/2013/960125. Epub 2012 Oct 01. PMID: 26317025; PMCID: PMC4437364.
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J Biomark. 2013;2013:960125. doi: 10.1155/2013/960125. Epub 2012 Oct 01.

Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats.

Journal of biomarkers

Kandaswamy Selvakumar, Senthamilselvan Bavithra, Sekaran Suganya, Firdous Ahmad Bhat, Gunasekaran Krishnamoorthy, Jagadeesan Arunakaran

Affiliations

  1. Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India.
  2. Department of Biochemistry, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu 603105, India.

PMID: 26317025 PMCID: PMC4437364 DOI: 10.1155/2013/960125

Abstract

Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.

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