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Walker EJ, Jensen LM, Croft S, et al. Variation in the nuclear effects of infection by different human rhinovirus serotypes. Front Microbiol. 2015;6:875doi: 10.3389/fmicb.2015.00875.
Walker, E. J., Jensen, L. M., Croft, S., & Ghildyal, R. (2015). Variation in the nuclear effects of infection by different human rhinovirus serotypes. Frontiers in microbiology, 6875. https://doi.org/10.3389/fmicb.2015.00875
Walker, Erin J, et al. "Variation in the nuclear effects of infection by different human rhinovirus serotypes." Frontiers in microbiology vol. 6 (2015): 875. doi: https://doi.org/10.3389/fmicb.2015.00875
Walker EJ, Jensen LM, Croft S, Ghildyal R. Variation in the nuclear effects of infection by different human rhinovirus serotypes. Front Microbiol. 2015 Aug 24;6:875. doi: 10.3389/fmicb.2015.00875. eCollection 2015. PMID: 26379650; PMCID: PMC4547043.
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Front Microbiol. 2015 Aug 24;6:875. doi: 10.3389/fmicb.2015.00875. eCollection 2015.

Variation in the nuclear effects of infection by different human rhinovirus serotypes.

Frontiers in microbiology

Erin J Walker, Lora M Jensen, Sarah Croft, Reena Ghildyal

Affiliations

  1. Centre for Research in Therapeutic Solutions, Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra ACT, Australia.

PMID: 26379650 PMCID: PMC4547043 DOI: 10.3389/fmicb.2015.00875

Abstract

Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localization of host proteins. A number of studies have identified differences between HRV serotypes, with respect to host response, protease activity and replicative ability. Here we report the sero-specific effects of two group-A HRV serotypes, the minor group HRV2 and the major group HRV16, on nuclear transport and nuclear protein localization. Using Western analysis, immunofluorescence and real time PCR, we show that HRV2 replicates at a faster rate than HRV16, which correlates with earlier production of viral proteases and disruption of host nuclear transport. There is significant variation in the nuclear effects of different rhinovirus species, which in turn may impact disease progression and patient response.

Keywords: human rhinovirus; nuclear transport; nucleoporin; serotype; viral proteases

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