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Tan DH, Szadkowski L, Raboud J, et al. Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy. Open Forum Infect Dis. 2015;2(2):ofv036doi: 10.1093/ofid/ofv036.
Tan, D. H., Szadkowski, L., Raboud, J., Yi, T. J., Shannon, B., Kaul, R., Liles, W. C., & Walmsley, S. (2015). Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy. Open forum infectious diseases, 2(2), ofv036. https://doi.org/10.1093/ofid/ofv036
Tan, Darrell H S, et al. "Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy." Open forum infectious diseases vol. 2,2 (2015): ofv036. doi: https://doi.org/10.1093/ofid/ofv036
Tan DH, Szadkowski L, Raboud J, Yi TJ, Shannon B, Kaul R, Liles WC, Walmsley S. Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy. Open Forum Infect Dis. 2015 Mar 09;2(2):ofv036. doi: 10.1093/ofid/ofv036. eCollection 2015 Apr. PMID: 26380337; PMCID: PMC4567101.
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Open Forum Infect Dis. 2015 Mar 09;2(2):ofv036. doi: 10.1093/ofid/ofv036. eCollection 2015 Apr.

Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy.

Open forum infectious diseases

Darrell H S Tan, Leah Szadkowski, Janet Raboud, Tae Joon Yi, Brett Shannon, Rupert Kaul, W Conrad Liles, Sharon Walmsley

Affiliations

  1. Departments of Medicine ; Division of Infectious Diseases , St. Michael's Hospital ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
  2. Toronto General Research Institute , University Health Network , Ontario, Canada.
  3. Dalla Lana School of Public Health , University of Toronto ; Toronto General Research Institute , University Health Network , Ontario, Canada.
  4. Immunology.
  5. Departments of Medicine ; Immunology ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
  6. Department of Medicine , University of Washington , Seattle.
  7. Departments of Medicine ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.

PMID: 26380337 PMCID: PMC4567101 DOI: 10.1093/ofid/ofv036

Abstract

We used generalized estimating equations to quantify the impact of recent vaccination or intercurrent infections on immune and inflammatory biomarkers among 144 human immunodeficiency virus (HIV)-infected adults with HIV RNA < 50 copies/mL on antiretroviral therapy. These events were associated with a 2.244 µg/mL increase in high sensitivity C-reactive protein and should be routinely assessed in future studies.

Keywords: C-reactive protein; HIV; immune activation; infections; inflammatory biomarkers; vaccinations

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