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Circelli L, Petrizzo A, Tagliamonte M, et al. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines (Basel). 2015;3(3):544-55doi: 10.3390/vaccines3030544.
Circelli, L., Petrizzo, A., Tagliamonte, M., Tornesello, M. L., Buonaguro, F. M., & Buonaguro, L. (2015). Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines, 3(3), 544-55. https://doi.org/10.3390/vaccines3030544
Circelli, Luisa, et al. "Systems Biology Approach for Cancer Vaccine Development and Evaluation." Vaccines vol. 3,3 (2015): 544-55. doi: https://doi.org/10.3390/vaccines3030544
Circelli L, Petrizzo A, Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L. Systems Biology Approach for Cancer Vaccine Development and Evaluation. Vaccines (Basel). 2015 Jul 14;3(3):544-55. doi: 10.3390/vaccines3030544. PMID: 26350594; PMCID: PMC4586466.
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Vaccines (Basel). 2015 Jul 14;3(3):544-55. doi: 10.3390/vaccines3030544.

Systems Biology Approach for Cancer Vaccine Development and Evaluation.

Vaccines

Luisa Circelli, Annacarmen Petrizzo, Maria Tagliamonte, Maria Lina Tornesello, Franco M Buonaguro, Luigi Buonaguro

Affiliations

  1. Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy. [email protected].
  2. Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy. [email protected].
  3. Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy. [email protected].
  4. Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy. [email protected].
  5. Laboratory of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale" - IRCCS, Naples 80131, Italy. [email protected].

PMID: 26350594 PMCID: PMC4586466 DOI: 10.3390/vaccines3030544

Abstract

Therapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines' efficacy. The newly developed high throughput technologies and computational tools are instrumental to this aim allowing the identification of more specific antigens and the comprehensive analysis of the innate and adaptive immunities. Here, we review the potentiality of systems biology in providing novel insights in the mechanisms of the action of vaccines to improve their design and effectiveness.

Keywords: cancer immunotherapy; cancer vaccine; systems vaccinology

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