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Ayada C, Toru Ü, Korkut Y. Nesfatin-1 and its effects on different systems. Hippokratia. 2015;19(1):4-10
Ayada, C., Toru, �. �., & Korkut, Y. (2015). Nesfatin-1 and its effects on different systems. Hippokratia, 19(1), 4-10.
Ayada, C, et al. "Nesfatin-1 and its effects on different systems." Hippokratia vol. 19,1 (2015): 4-10.
Ayada C, Toru Ü, Korkut Y. Nesfatin-1 and its effects on different systems. Hippokratia. 2015 Jan-Mar;19(1):4-10. PMID: 26435639; PMCID: PMC4574585.
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Hippokratia. 2015 Jan-Mar;19(1):4-10.

Nesfatin-1 and its effects on different systems.

Hippokratia

C Ayada, Ü Toru, Y Korkut

Affiliations

  1. Department of Physiology, Medical Faculty, Dumlup?nar University, Kütahya, Turkey.
  2. Department of Chest Diseases, Medical Faculty, Dumlup?nar University, Kütahya, Turkey.
  3. Department of Family Medicine, Medical Faculty, Dumlup?nar University, Kütahya, Turkey.

PMID: 26435639 PMCID: PMC4574585

Abstract

Nesfatin-1 is a peptide secreted by peripheral tissues, central and peripheral nervous system. It is involved in the regulation of energy homeostasis related with food regulation and water intake. Nesfatin-1 can pass through the blood-brain barrier in both directions. It suppresses feeding independently from the leptin pathway and increases insulin secretion from pancreatic beta islet cells. That is why nesfatin-1 has drawn attention as a new therapeutic agent, especially for the treatment of obesity and diabetes mellitus. Its effects on nutrition have been studied in more detail in literature. On the other hand, its effects on other physiological parameters and mechanisms of action still need to be clarified. Synthesizing the research on nesfatin-1 can help us better understand this field. Hippokratia 2015, 19 (1): 4-10.

Keywords: Human nesfatin-1 protein; L-type calcium channels; anti-obesity agents; appetite depressants; human nucleobinding 2 protein; nerve tissue proteins

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