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Andrabi SS, Parvez S, Tabassum H. Melatonin and Ischemic Stroke: Mechanistic Roles and Action. Adv Pharmacol Sci. 2015;2015:384750doi: 10.1155/2015/384750.
Andrabi, S. S., Parvez, S., & Tabassum, H. (2015). Melatonin and Ischemic Stroke: Mechanistic Roles and Action. Advances in pharmacological sciences, 2015384750. https://doi.org/10.1155/2015/384750
Andrabi, Syed Suhail, et al. "Melatonin and Ischemic Stroke: Mechanistic Roles and Action." Advances in pharmacological sciences vol. 2015 (2015): 384750. doi: https://doi.org/10.1155/2015/384750
Andrabi SS, Parvez S, Tabassum H. Melatonin and Ischemic Stroke: Mechanistic Roles and Action. Adv Pharmacol Sci. 2015;2015:384750. doi: 10.1155/2015/384750. Epub 2015 Sep 07. PMID: 26435711; PMCID: PMC4575994.
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Adv Pharmacol Sci. 2015;2015:384750. doi: 10.1155/2015/384750. Epub 2015 Sep 07.

Melatonin and Ischemic Stroke: Mechanistic Roles and Action.

Advances in pharmacological sciences

Syed Suhail Andrabi, Suhel Parvez, Heena Tabassum

Affiliations

  1. Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
  2. Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India ; Department of Biochemistry, Jamia Hamdard (Hamdard University), New Delhi 110062, India.

PMID: 26435711 PMCID: PMC4575994 DOI: 10.1155/2015/384750

Abstract

Stroke is one of the most devastating neurological disabilities and brain's vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca(2+) level, and so forth. Melatonin is a neurohormone secreted by pineal and extra pineal tissues responsible for various physiological processes like sleep and mood behaviour. Melatonin has been implicated in various neurological diseases because of its antioxidative, antiapoptotic, and anti-inflammatory properties. We have previously reviewed the neuroprotective effect of melatonin in various models of brain injury like traumatic brain injury and spinal cord injury. In this review, we have put together the various causes and consequence of stroke and protective role of melatonin in ischemic stroke.

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