Display options
Cite
Chaudhary AK, Aneja GK, Shukla S, et al. Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C). J Clin Diagn Res. 2015;9(8):OC20-2doi: 10.7860/JCDR/2015/13348.6376.
Chaudhary, A. K., Aneja, G. K., Shukla, S., & Razi, S. M. (2015). Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C). Journal of clinical and diagnostic research : JCDR, 9(8), OC20-2. https://doi.org/10.7860/JCDR/2015/13348.6376
Chaudhary, Abhay Kumar, et al. "Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C)." Journal of clinical and diagnostic research : JCDR vol. 9,8 (2015): OC20-2. doi: https://doi.org/10.7860/JCDR/2015/13348.6376
Chaudhary AK, Aneja GK, Shukla S, Razi SM. Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C). J Clin Diagn Res. 2015 Aug;9(8):OC20-2. doi: 10.7860/JCDR/2015/13348.6376. Epub 2015 Aug 01. PMID: 26435985; PMCID: PMC4576578.
Copy Download .nbib Format: NLM
Share it on

J Clin Diagn Res. 2015 Aug;9(8):OC20-2. doi: 10.7860/JCDR/2015/13348.6376. Epub 2015 Aug 01.

Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C).

Journal of clinical and diagnostic research : JCDR

Abhay Kumar Chaudhary, Girish Kumar Aneja, Shubhra Shukla, Syed Mohd Razi

Affiliations

  1. Senior Resident, Department of Internal Medicine, ESI PGIMER , New Delhi, India .
  2. Professor and Head, Department of Medicine, LLRM Medical Colllege , Meerut, India .
  3. Post Graduate, Department of Dermatology, Stanley Medical College , Chennai, India .
  4. Senior Resident, Department of Endocrinology and Metabolism, LLRM Medical College , Meerut, India .

PMID: 26435985 PMCID: PMC4576578 DOI: 10.7860/JCDR/2015/13348.6376

Abstract

INTRODUCTION: Left ventricular diastolic dysfunction (LVDD) represents the first stage of diabetic cardiomyopathy preceding changes in systolic function, reinforcing the importance of early examination of ventricular function in individuals with diabetes mellitus (DM). This cross-sectional study was conducted to determine the incidence of asymptomatic LVDD in newly diagnosed normotensive cases of type 2 diabetes subjects, and its relation to glycosylated haemoglobin (HbA1C), age at the time of diagnosis, body mass index (BMI) and serum total cholesterol.

AIM AND OBJECTIVE: To study the incidence of left ventricular diastolic dysfunction (LVDD) and its correlation with HbA1C in normotensive, newly diagnosed type 2 diabetic patients.

MATERIALS AND METHODS: This cross-sectional study was done in western U.P. on 100 patients of newly diagnosed (within 1 month) type 2 DM between patients 30 and 60 years of age, visiting the Medicine and Endocrinology outpatient Department of LLRM Medical College, Meerut. Patients with established type 2 diabetes and already taking antidiabetic treatment, cardiac diseases like valvular heart disease, ischemic and hypertensive heart disease, congestive heart failure, cardiomyopathy, renal failure, chronic pulmonary disease, severe anaemia and haemoglobinopathies were excluded from the study. These patients were informed about the study and informed consent was obtained before proceeding with the investigations. Patients selected were evaluated with relevant investigations like fasting and post prandial blood sugar, HbA1C level, lipid profile and 2D echocardiography to assess LVDD. These selected patients were divided in 2 groups; one with left ventricular diastolic dysfunction (LVDD) and second group of subjects without LVDD. Various parameters like HbA1C, age, body mass index and serum cholesterol were evaluated between these 2 groups. Statistical analysis was performed using Student t-test, Chi-square and Fisher Exact-test.

RESULTS: Out of 100 patients 65 were males and 35 females. Mean age of the population was 50.08 ± 6.32 years. Overall incidence of LVDD was 41%. Grade 1 LVDD was most common. Mean HbA1C level of LVDD group was found higher as compared to those without LVDD.

CONCLUSION: LVDD is very common at the time of diagnosis of type 2 DM even in normotensive patients independent of confounding effect of hypertension, ischemia and BMI. HbA1C and age, were found to be strong indicators of LVDD in newly diagnosed cases of Type 2 DM.

Keywords: BMI; Diabetic cardiomyopathy; Normotensive

References

  1. Diabetologia. 2011 Dec;54(12):3022-7 - PubMed
  2. Diabetes Metab. 2003 Nov;29(5):455-66 - PubMed
  3. Am J Cardiol. 1992 Aug 1;70(3):371-8 - PubMed
  4. J Assoc Physicians India. 2012 May;60:23-6 - PubMed
  5. Am J Cardiol. 2009 May 15;103(10 ):1463-6 - PubMed
  6. Am J Med. 2004 Mar 8;116 Suppl 5A:64S-75S - PubMed
  7. J Cardiovasc Dis Res. 2011 Oct;2(4):213-22 - PubMed
  8. Lancet. 2014 Jun 7;383(9933):1947-8 - PubMed
  9. JNMA J Nepal Med Assoc. 2009 Jan-Mar;48(173):20-3 - PubMed
  10. J Intern Med. 2002 May;251(5):415-20 - PubMed
  11. Am J Cardiol. 1995 Dec 1;76(16):1173-6 - PubMed
  12. Cardiol J. 2010;17(6):558-65 - PubMed
  13. Clin Sci (Lond). 2003 Nov;105(5):591-9 - PubMed

Publication Types