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J Exp Zool A Ecol Genet Physiol. 2015 Dec;323(10):714-721. doi: 10.1002/jez.1964. Epub 2015 Sep 09.

Sex steroid hormone secretion in the wall lizard Podarcis sicula testis: The involvement of VIP.

Journal of experimental zoology. Part A, Ecological genetics and physiology

Luigi Rosati, Marina Prisco, Maria Maddalena Di Fiore, Alessandra Santillo, Rosaria Sciarrillo, Salvatore Valiante, Vincenza Laforgia, Francesca Coraggio, Piero Andreuccetti, Marisa Agnese

Affiliations

  1. Dipartimento di Biologia, Università degli Studi di Napoli Federico II, Naples, Italy.
  2. Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy.
  3. Dipartimento di Scienze e Tecnologie, Università degli Studi del Sannio, Benevento, Italy.

PMID: 26351243 DOI: 10.1002/jez.1964

Abstract

Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide involved in different functions, including testosterone synthesis. Recently, we reported the presence of VIP in the testis of Podarcis sicula, throughout the reproductive cycle. Now, we investigated the effects of the VIP on steroidogenesis in significant periods of the Podarcis reproductive cycle: winter stasis, reproductive period, and summer stasis. Using VIP treatments in testis culture in absence or presence of receptors antagonists, we demonstrated for the first time that in P. sicula, VIP is involved not only in testosterone synthesis, as in mammals, but in 17β-estradiol synthesis too. J. Exp. Zool. 323A: 714-721, 2015. © 2015 Wiley Periodicals, Inc.

© 2015 Wiley Periodicals, Inc.

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