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Sato M, Mizuno Y, Matsuyama K, et al. Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis. Case Rep Dermatol. 2015;7(2):161-5doi: 10.1159/000437251.
Sato, M., Mizuno, Y., Matsuyama, K., Shu, E., Kanoh, H., Suwa, T., & Seishima, M. (2015). Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis. Case reports in dermatology, 7(2), 161-5. https://doi.org/10.1159/000437251
Sato, Mika, et al. "Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis." Case reports in dermatology vol. 7,2 (2015): 161-5. doi: https://doi.org/10.1159/000437251
Sato M, Mizuno Y, Matsuyama K, Shu E, Kanoh H, Suwa T, Seishima M. Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis. Case Rep Dermatol. 2015 Jul 24;7(2):161-5. doi: 10.1159/000437251. eCollection 2015. PMID: 26351424; PMCID: PMC4560312.
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Case Rep Dermatol. 2015 Jul 24;7(2):161-5. doi: 10.1159/000437251. eCollection 2015.

Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis.

Case reports in dermatology

Mika Sato, Yuki Mizuno, Kanako Matsuyama, En Shu, Hiroyuki Kanoh, Tetsuya Suwa, Mariko Seishima

Affiliations

  1. Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
  2. Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.

PMID: 26351424 PMCID: PMC4560312 DOI: 10.1159/000437251

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.

Keywords: Cytomegalovirus; Drug rash with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome; Human herpesvirus 6; Subacute thyroiditis

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