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Mikami H, Ishimura N, Fukazawa K, et al. Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. J Neurogastroenterol Motil. 2016;22(1):112-7doi: 10.5056/jnm15130.
Mikami, H., Ishimura, N., Fukazawa, K., Okada, M., Izumi, D., Shimura, S., Okimoto, E., Aimi, M., Ishihara, S., & Kinoshita, Y. (2016). Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. Journal of neurogastroenterology and motility, 22(1), 112-7. https://doi.org/10.5056/jnm15130
Mikami, Hironobu, et al. "Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers." Journal of neurogastroenterology and motility vol. 22,1 (2016): 112-7. doi: https://doi.org/10.5056/jnm15130
Mikami H, Ishimura N, Fukazawa K, Okada M, Izumi D, Shimura S, Okimoto E, Aimi M, Ishihara S, Kinoshita Y. Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers. J Neurogastroenterol Motil. 2016 Jan 31;22(1):112-7. doi: 10.5056/jnm15130. PMID: 26507875; PMCID: PMC4699728.
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J Neurogastroenterol Motil. 2016 Jan 31;22(1):112-7. doi: 10.5056/jnm15130.

Effects of Metoclopramide on Esophageal Motor Activity and Esophagogastric Junction Compliance in Healthy Volunteers.

Journal of neurogastroenterology and motility

Hironobu Mikami, Norihisa Ishimura, Kousuke Fukazawa, Mayumi Okada, Daisuke Izumi, Shino Shimura, Eiko Okimoto, Masahito Aimi, Shunji Ishihara, Yoshikazu Kinoshita

Affiliations

  1. Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
  2. Department of Gastroenterology and Hepatology, Kasai City Hospital, Kasai, Japan.

PMID: 26507875 PMCID: PMC4699728 DOI: 10.5056/jnm15130

Abstract

BACKGROUND/AIMS: Prokinetic drugs such as metoclopramide are frequently used as second-line therapy for patients with gastroesophageal reflux disease. However, their beneficial effects remain unclear. Esophageal motor activities and compliance of the esophagogastric junction (EGJ) are important for prevention of gastroesophageal reflux. Although metoclopramide has been reported to increase lower esophageal sphincter (LES) pressure, its effects on EGJ compliance have not been evaluated. In the present study, we investigated the effects of metoclopramide on esophageal motor activities and EGJ compliance.

METHODS: Nine healthy male volunteers without abdominal symptoms were enrolled. Peristaltic esophageal contractions and LES pressure were examined using high-resolution esophageal manometry, while EGJ compliance was evaluated with an endoluminal functional lumen-imaging probe. After obtaining baseline values for esophageal motor activities and EGJ compliance, metoclopramide (10 mg) was intravenously administered, then all measurements were repeated at 15 minutes after administration in each subject.

RESULTS: Following administration of metoclopramide, mean resting LES pressure was significantly increased as compared with the baseline (13.7 ± 9.2 vs 26.7 ± 8.8 mmHg, P < 0.05). In addition, metoclopramide significantly augmented peristaltic contractions, especially in the distal esophageal segment (P < 0.05). On the other hand, distensibility index did not change after administration (4.5 ± 0.5 vs 4.1 ± 0.5 mm(2)/mmHg), suggesting no significant effect of metoclopramide on EGJ compliance.

CONCLUSIONS: Metoclopramide augmented esophageal contractions without changing EGJ compliance in healthy adults.

Keywords: Esophageal sphincter; Esophagogastric junction; Manometry; Metoclopramide; Motor Activity; lower

References

  1. Neurogastroenterol Motil. 2013 Nov;25(11):904-10 - PubMed
  2. Am J Physiol Gastrointest Liver Physiol. 2008 Nov;295(5):G920-33 - PubMed
  3. Clin Endocrinol (Oxf). 1980 May;12(5):435-40 - PubMed
  4. Aliment Pharmacol Ther. 2011 Feb;33(3):323-32 - PubMed
  5. Gastrointest Endosc. 2010 Aug;72 (2):272-8 - PubMed
  6. Gut. 1973 May;14(5):380-2 - PubMed
  7. J Gastrointest Surg. 2011 Jul;15(7):1112-20 - PubMed
  8. Pharmacol Biochem Behav. 1980 Jun;12(6):871-3 - PubMed
  9. AJR Am J Roentgenol. 1988 Jul;151(1):49-56 - PubMed
  10. Aliment Pharmacol Ther. 2007 Jul 15;26(2):149-60 - PubMed
  11. Gastroenterology. 1981 Aug;81(2):376-94 - PubMed
  12. Dig Dis Sci. 2002 Mar;47(3):652-6 - PubMed
  13. Dig Dis Sci. 1979 Apr;24(4):289-95 - PubMed
  14. Dig Dis Sci. 2009 Aug;54(8):1686-92 - PubMed
  15. J Neurogastroenterol Motil. 2012 Apr;18(2):181-6 - PubMed
  16. Dig Dis Sci. 2012 Jun;57(6):1609-17 - PubMed
  17. J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):70-5 - PubMed
  18. Ann Surg. 2005 Jul;242(1):43-8 - PubMed
  19. N Engl J Med. 1982 Dec 16;307(25):1547-52 - PubMed
  20. Br J Clin Pharmacol. 2010 Aug;70(2):171-9 - PubMed
  21. Aliment Pharmacol Ther. 2004 Dec;20 Suppl 9:14-25 - PubMed
  22. Anesthesiology. 2008 Nov;109(5):806-10 - PubMed
  23. Gastroenterology. 2003 Oct;125(4):1018-24 - PubMed
  24. Scand J Gastroenterol. 1976;11(6):629-34 - PubMed
  25. Br J Anaesth. 1978 Mar;50(3):295-8 - PubMed
  26. J Gastroenterol. 1999 Aug;34(4):441-4 - PubMed
  27. Arzneimittelforschung. 1993 Oct;43(10):1084-94 - PubMed
  28. Gastroenterology. 1986 Oct;91(4):897-904 - PubMed
  29. J Gastroenterol. 2014 Sep;49(9):1307-13 - PubMed
  30. J Gastroenterol Hepatol. 2010 Jun;25(6):1066-71 - PubMed
  31. Am J Gastroenterol. 2004 Nov;99(11):2088-93 - PubMed
  32. Br Med J. 1973 Feb 24;1(5851):446-8 - PubMed
  33. Gastroenterology. 2000 Apr;118(4):688-95 - PubMed

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