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Lepeltier EA, Nuhn L, Lehr CM, et al. Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine. Nanomedicine (Lond). 2015;10(20):3147-66doi: 10.2217/nnm.15.132.
Lepeltier, E. A., Nuhn, L., Lehr, C. M., & Zentel, R. (2015). Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine. Nanomedicine (London, England), 10(20), 3147-66. https://doi.org/10.2217/nnm.15.132
Lepeltier, Elise Anne, et al. "Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine." Nanomedicine (London, England) vol. 10,20 (2015): 3147-66. doi: https://doi.org/10.2217/nnm.15.132
Lepeltier EA, Nuhn L, Lehr CM, Zentel R. Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine. Nanomedicine (Lond). 2015;10(20):3147-66. doi: 10.2217/nnm.15.132. Epub 2015 Oct 08. PMID: 26447353.
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Nanomedicine (Lond). 2015;10(20):3147-66. doi: 10.2217/nnm.15.132. Epub 2015 Oct 08.

Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.

Nanomedicine (London, England)

Elise Anne Lepeltier, Lutz Nuhn, Claus-Michael Lehr, Rudolf Zentel

Affiliations

  1. Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123 Saarbrücken, Germany.
  2. Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
  3. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
  4. Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, Mainz, Germany.

PMID: 26447353 DOI: 10.2217/nnm.15.132

Abstract

During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further improved therapeutic concepts against several diseases in the future too.

Keywords: epithelial barriers; immunotherapy; intra- and extra-cellular bacteria; nanomedicines; vaccination

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