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Oh JH, Oh DJ, Koo SM, et al. Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. Tuberc Respir Dis (Seoul). 2015;78(4):401-7doi: 10.4046/trd.2015.78.4.401.
Oh, J. H., Oh, D. J., Koo, S. M., Kim, Y. K., Kim, K. U., Kim, H. J., Kim, D. W., & Uh, S. T. (2015). Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. Tuberculosis and respiratory diseases, 78(4), 401-7. https://doi.org/10.4046/trd.2015.78.4.401
Oh, Ji Hyun, et al. "Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia." Tuberculosis and respiratory diseases vol. 78,4 (2015): 401-7. doi: https://doi.org/10.4046/trd.2015.78.4.401
Oh JH, Oh DJ, Koo SM, Kim YK, Kim KU, Kim HJ, Kim DW, Uh ST. Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia. Tuberc Respir Dis (Seoul). 2015 Oct;78(4):401-7. doi: 10.4046/trd.2015.78.4.401. Epub 2015 Oct 01. PMID: 26508933; PMCID: PMC4620339.
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Tuberc Respir Dis (Seoul). 2015 Oct;78(4):401-7. doi: 10.4046/trd.2015.78.4.401. Epub 2015 Oct 01.

Different Responses to Clarithromycin in Patients with Cryptogenic Organizing Pneumonia.

Tuberculosis and respiratory diseases

Ji Hyun Oh, Dong Jun Oh, So-My Koo, Yang Ki Kim, Ki Up Kim, Hyun Jo Kim, Dong Won Kim, Soo-Taek Uh

Affiliations

  1. Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
  2. Department of Thoracic Surgery, Soonchunhyang University Hospital, Seoul, Korea.
  3. Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea.

PMID: 26508933 PMCID: PMC4620339 DOI: 10.4046/trd.2015.78.4.401

Abstract

Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by a subacute course and favorable prognosis with corticosteroids. However, some patients show resistance to steroids. Macrolides have been used with success in those patients showing resistance to steroids. A few reports showed treatment failure with macrolides in patients with COP who were resistant to steroids. In this report, we described two cases of COP who showed different responses to clarithromycin. One recovered completely, but the other gradually showed lung fibrosis with clarithromycin.

Keywords: Adrenal Cortex Hormones; Clarithromycin; Cryptogenic Organizing Pneumonia; Macrolides

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