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Guellec D, Milin M, Cornec D, et al. Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort. RMD Open. 2015;1(1):e000070doi: 10.1136/rmdopen-2015-000070.
Guellec, D., Milin, M., Cornec, D., Tobon, G. J., Marhadour, T., Jousse-Joulin, S., Chiocchia, G., Vittecocq, O., Devauchelle-Pensec, V., & Saraux, A. (2015). Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort. RMD open, 1(1), e000070. https://doi.org/10.1136/rmdopen-2015-000070
Guellec, Dewi, et al. "Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort." RMD open vol. 1,1 (2015): e000070. doi: https://doi.org/10.1136/rmdopen-2015-000070
Guellec D, Milin M, Cornec D, Tobon GJ, Marhadour T, Jousse-Joulin S, Chiocchia G, Vittecocq O, Devauchelle-Pensec V, Saraux A. Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort. RMD Open. 2015 Jul 15;1(1):e000070. doi: 10.1136/rmdopen-2015-000070. eCollection 2015. PMID: 26509068; PMCID: PMC4613150.
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RMD Open. 2015 Jul 15;1(1):e000070. doi: 10.1136/rmdopen-2015-000070. eCollection 2015.

Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort.

RMD open

Dewi Guellec, Morgane Milin, Divi Cornec, Gabriel J Tobon, Thierry Marhadour, Sandrine Jousse-Joulin, Gilles Chiocchia, Olivier Vittecocq, Valérie Devauchelle-Pensec, Alain Saraux

Affiliations

  1. Department of Rheumatology , CHU de la Cavale Blanche, Boulevard Tanguy Prigent , Brest , France.
  2. Department of Rheumatology , CHU de la Cavale Blanche, Boulevard Tanguy Prigent , Brest , France ; EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale , Brest , France.
  3. Department of Internal Medicine, Division of Rheumatology , Fundación Valle del Lili, ICESI University School of Medicine , Cali , Columbia.
  4. Simone Veil Department of Health Sciences , Inserm U1173, University Versailles-Saint-Quentin , Montigny-Le-Bretonneux, Ile de France , France.
  5. Rhumatologie & Inserm, U905 (IRIB) CIC 1404, CHU Hôpitaux de Rouen , Rouen , France.

PMID: 26509068 PMCID: PMC4613150 DOI: 10.1136/rmdopen-2015-000070

Abstract

OBJECTIVES: To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.

METHODS: We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm(3), at baseline and after 3 years. Features of patients with and without baseline eosinophilia were compared.

RESULTS: Baseline eosinophilia was evidenced in 26 of 804 (3.2%) patients; their mean eosinophil count was 637.7±107/mm(3). Baseline eosinophilia was ascribed to atopic syndrome in 6 of 26 (23.1%) patients. After 3 years, patients with eosinophilia had higher Health Assessment Questionnaire scores (0.9 vs 0.5, p=0.004), higher patient visual analogue scale activity score and morning stiffness intensity (p=0.05), and were more often taking disease-modifying antirheumatic drugs (p=0.02). Baseline eosinophilia was not associated with presence of extra-articular manifestations.

CONCLUSIONS: Eosinophilia is rare in recent-onset arthritis suggestive of RA, and is usually directly related to the rheumatic disease. Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without.

Keywords: DMARDs (biologic); DMARDs (synthetic); Early Rheumatoid Arthritis; Rheumatoid Arthritis

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